Interaction between blood-brain barrier and glymphatic system in solute clearance

被引:97
作者
Verheggen, I. C. M. [1 ]
Van Boxtel, M. P. J. [1 ]
Verhey, F. R. J. [1 ]
Jansen, J. F. A. [2 ]
Backes, W. H. [2 ]
机构
[1] Maastricht Univ, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, POB 616, NL-6200 MD Maastricht, Netherlands
[2] Maastricht Univ, Med Ctr, Dept Radiol & Nucl Med, Sch Mental Hlth & Neurosci, POB 5800, NL-6202 AZ Maastricht, Netherlands
关键词
Blood-brain barrier; BBB; Glymphatic system; Clearance; Amyloid-beta; Alzheimer's disease; Imaging; SMALL VESSEL DISEASE; AMYLOID CASCADE HYPOTHESIS; CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; MOUSE MODEL; BETA-PEPTIDE; A-BETA; TRANSPORT; DEMENTIA;
D O I
10.1016/j.neubiorev.2018.03.028
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Neurovascular pathology concurs with protein accumulation, as the brain vasculature is important for waste clearance. Interstitial solutes, such as amyloid-beta, were previously thought to be primarily cleared from the brain by blood-brain barrier transport. Recently, the glymphatic system was discovered, in which cerebrospinal fluid is exchanged with interstitial fluid, facilitated by the aquaporin-4 water channels on the astroglial endfeet. Glymphatic flow can clear solutes from the interstitial space. Blood-brain barrier transport and glymphatic clearance likely serve complementary roles with partially overlapping mechanisms providing a well-conditioned neuronal environment. Disruption of these mechanisms can lead to protein accumulation and may initiate neurodegenerative disorders, for instance amyloid-beta accumulation and Alzheimer's disease. Although both mechanisms seem to have a similar purpose, their interaction has not been clearly discussed previously. This review focusses on this interaction in healthy and pathological conditions. Future health initiatives improving waste clearance might delay or even prevent onset of neurodegenerative disorders. Defining glymphatic flow kinetics using imaging may become an alternative way to identify those at risk of Alzheimer's disease.
引用
收藏
页码:26 / 33
页数:8
相关论文
共 50 条
  • [11] A Multifaceted Role for apoE in the Clearance of Beta-Amyloid across the Blood-Brain Barrier
    Bachmeier, Corbin
    Paris, Daniel
    Beaulieu-Abdelahad, David
    Mouzon, Benoit
    Mullan, Michael
    Crawford, Fiona
    [J]. NEURODEGENERATIVE DISEASES, 2013, 11 (01) : 13 - 21
  • [12] The Blood-Brain Barrier: Regulatory Roles in Wakefulness and Sleep
    Pan, Weihong
    Kastin, Abba J.
    [J]. NEUROSCIENTIST, 2017, 23 (02) : 124 - 136
  • [13] Healthy aging and the blood-brain barrier
    Banks, William A.
    Reed, May J.
    Logsdon, Aric F.
    Rhea, Elizabeth M.
    Erickson, Michelle A.
    [J]. NATURE AGING, 2021, 1 (03): : 243 - 254
  • [14] Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function
    Wen, Jing
    Satyanarayanan, Senthil Kumaran
    Li, Ang
    Yan, Lingli
    Zhao, Ziai
    Yuan, Qiuju
    Su, Kuan-Pin
    Su, Huanxing
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2024, 115 : 335 - 355
  • [15] Differences in amyloid-β clearance across mouse and human blood-brain barrier models: Kinetic analysis and mechanistic modeling
    Qosa, Hisham
    Abuasal, Bilal S.
    Romero, Ignacio A.
    Weksler, Babette
    Couraud, Pierre-Oliver
    Keller, Jeffrey N.
    Kaddoumi, Amal
    [J]. NEUROPHARMACOLOGY, 2014, 79 : 668 - 678
  • [16] In vivo methods for imaging blood-brain barrier function and dysfunction
    Harris, William James
    Asselin, Marie-Claude
    Hinz, Rainer
    Parkes, Laura Michelle
    Allan, Stuart
    Schiessl, Ingo
    Boutin, Herve
    Dickie, Ben Robert
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 50 (04) : 1051 - 1083
  • [17] Addressing Blood-Brain Barrier Impairment in Alzheimer's Disease
    Sharma, Chanchal
    Woo, Hanwoong
    Kim, Sang Ryong
    [J]. BIOMEDICINES, 2022, 10 (04)
  • [18] Peripheral Routes to Neurodegeneration: Passing Through the Blood-Brain Barrier
    Giannoni, Patrizia
    Claeysen, Sylvie
    Noe, Francesco
    Marchi, Nicola
    [J]. FRONTIERS IN AGING NEUROSCIENCE, 2020, 12
  • [19] Disturbance of Intracerebral Fluid Clearance and Blood-Brain Barrier in Vascular Cognitive Impairment
    Ueno, Masaki
    Chiba, Yoichi
    Murakami, Ryuta
    Matsumoto, Koichi
    Fujihara, Ryuji
    Uemura, Naoya
    Yanase, Ken
    Kamada, Masaki
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (10)
  • [20] Amyloid Deposition and Influx Transporter Expression at the Blood-Brain Barrier Increase in Normal Aging
    Silverberg, Gerald D.
    Miller, Miles C.
    Messier, Arthur A.
    Majmudar, Samir
    Machan, Jason T.
    Donahue, John E.
    Stopa, Edward G.
    Johanson, Conrad E.
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2010, 69 (01) : 98 - 108