MARK-AGE standard operating procedures (SOPs): A successful effort

被引：38

作者：

Moreno-Villanueva, Maria ^{[1
]}

Capri, Miriam ^{[2
]}

Breusing, Nicolle ^{[3
]}

Siepelmeyer, Anne ^{[4
]}

Sevini, Federica ^{[2
]}

Ghezzo, Alessandro ^{[8
]}

de Craen, Anton J. M. ^{[5
]}

Hervonen, Antti ^{[6
]}

Hurme, Mikko ^{[6
]}

Schoen, Christiane ^{[4
]}

Grune, Tilman ^{[3
,7
]}

Franceschi, Claudio ^{[2
]}

Buerkle, Alexander ^{[1
]}

机构：

[1] Univ Konstanz, Dept Biol, Mol Toxicol Grp, D-78457 Constance, Germany

[2] Univ Bologna, CIG Interdepartmentall Ctr L Galvani, DIMES Dept Expt Diagnost & Specialty Med, Alma Mater Studiorum, I-40126 Bologna, Italy

[3] Univ Hohenheim, Inst Nutr Med, D-70599 Stuttgart, Germany

[4] BioTeSys GmbH, D-73728 Esslingen, Germany

[5] Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands

[6] Univ Tampere, Sch Med, Tampere 33014, Finland

[7] German Inst Human Nutr, D-14558 Nuthetal, Germany

[8] Natl Assoc Famiglie Persone Con Disabilita Affett, Macerata, Italy

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2015年 / 151卷

关键词：

Standard operating procedures; Biobank; Human studies; SCALE;

D O I：

10.1016/j.mad.2015.03.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Within the MARK-AGE project, a population study (3337 subjects) was conducted to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any single marker. The MARK-AGE project involves 14 European countries and a total of 26 research centres. In such a study, standard operating procedures (SOPs) are an essential task, which are binding for all MARK-AGE Beneficiaries. The SOPs cover all aspects of subject's recruitment, collection, shipment and distribution of biological samples (blood and its components, buccal mucosa cells or BMC and urine) as well as the anthropometric measurements and questionnaires. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：18 / 25

页数：8

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