Studies on synthesis of pyrimidine derivatives and their antimicrobial activity

被引：42

作者：

Mallikarjunaswamy, C. ^{[1
]}

Mallesha, L. ^{[2
]}

Bhadregowda, D. G. ^{[3
]}

Pinto, Othbert ^{[1
]}

机构：

[1] St Philomenas Coll, PG Dept Studies Chem, Mysore 15, Karnataka, India

[2] JSS Coll Arts Commerce & Sci, PG Dept Studies Chem, Ooty Rd, Mysore 25, Karnataka, India

[3] Univ Mysore, Dept Chem, Yuvarajas Coll, Mysore 5, Karnataka, India

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2017年 / 10卷

关键词：

Pyrimidine derivatives; Sulfonyl chlorides; Antimicrobial activity;

D O I：

10.1016/j.arabjc.2012.10.008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel 2-(5-bromo-2-chloro-pyrimidin-4-ylsulfanyl)-4-methoxy-phenylamine derivatives were synthesized by the reaction of 2-(5-bromo-2-chloro-pyrimidin-4-ylsulfanyl)-4-methoxy-phenylamine with various sulfonyl chlorides, and their in vitro antimicrobial activity was evaluated. The synthesized compounds were characterized by elemental analyses, FT-IR, H-1 NMR and LC-MS spectral studies. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：S484 / S490

页数：7

共 15 条

[1]

Andriole VT, 1998, CURR CLIN TOPICS INF, V18, P19

[2] The fluoroquinolone antibacterials: past, present and future perspectives [J].

Appelbaum, PC ;

Hunter, PA .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 16 (01) :5-15

[3]

BAUER AW, 1966, AM J CLIN PATHOL, V45, P493

[4]

Brown D.J., 1962, CHEM HETEROCYCL COM+, P16

[5] Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells [J].

Chang, Sheng ;

Yin, Shi-Liang ;

Wang, Jian ;

Jing, Yong-Kui ;

Dong, Jin-Hua .

MOLECULES, 2009, 14 (10) :4166-4179

[6] BETA-LACTAMASES AND BACTERIAL-RESISTANCE TO ANTIBIOTICS [J].

FRERE, JM .

MOLECULAR MICROBIOLOGY, 1995, 16 (03) :385-395

[7]

GHONEIM KM, 1986, J INDIAN CHEM SOC, V63, P914

[8]

Karale BK, 2002, INDIAN J CHEM B, V41, P1957

[9] A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation [J].

Keche, Ashish P. ;

Hatnapure, Girish D. ;

Tale, Rajesh H. ;

Rodge, Atish H. ;

Birajdar, Satish S. ;

Kamble, Vandana M. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (10) :3445-3448

[10]

Kenner G.W., 1957, Heterocyclic Compounds, P6

← 1 2 →