Quantitative phase-contrast tomography of a liquid phantom using a conventional x-ray tube source

被引：97

作者：

Herzen, Julia ^{[1
]}

Donath, Tilman ^{[2
]}

Pfeiffer, Franz ^{[2
,3
]}

Bunk, Oliver ^{[2
]}

Padeste, Celestino ^{[2
]}

Beckmann, Felix ^{[1
]}

Schreyer, Andreas ^{[1
]}

David, Christian ^{[2
]}

机构：

[1] GKSS Forschungszentrum Geesthacht GmbH, D-21502 Geesthacht, Germany

[2] Paul Scherrer Inst, CH-5232 Villigen, Switzerland

[3] Ecole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland

来源：

OPTICS EXPRESS | 2009年 / 17卷 / 12期

关键词：

COMPUTED-TOMOGRAPHY; LABORATORY SOURCE; RESOLUTION; INTERFEROMETER; MICROSCOPY; MICROTOMOGRAPHY;

D O I：

10.1364/OE.17.010010

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Over the last few years, differential phase-contrast x-ray computed tomography (PC-CT) using a hard x-ray grating interferometer and polychromatic x-ray tube sources has been developed. The method allows for simultaneous determination of the attenuation coefficient and the refractive index decrement distribution inside an object in three dimensions. Here we report experimental results of our investigation on the quantitativeness and accuracy of this method. For this study, a phantom consisting of several tubes filled with chemically well-defined liquids was built and measured in PC-CT. We find, that the measured attenuation coefficients and refractive index decrements closely match calculated, theoretical values. Moreover, the study demonstrates, how substances with similar attenuation coefficient or refractive index decrement, can be uniquely distinguished by the simultaneous, quantitative measurement of both quantities. (C) 2009 Optical Society of America

引用

页码：10010 / 10018

页数：9

共 30 条

[1]

Als-Nielsen J., 2008, Elements of Modern X-ray Physics

[2]

[Anonymous], 1987, PRINCIPLES COMPUTERI

[3] Phase Imaging Using A Polychromatic X-ray Laboratory Source [J].

Arhatari, B. D. ;

Hannah, K. ;

Balaur, E. ;

Peele, A. G. .

OPTICS EXPRESS, 2008, 16 (24) :19950-19956

[4] Three-dimensional imaging of nerve tissue by x-ray phase-contrast microtomography [J].

Beckmann, F ;

Heise, K ;

Kölsch, B ;

Bonse, U ;

Rajewsky, MF ;

Bartscher, M ;

Biermann, T .

BIOPHYSICAL JOURNAL, 1999, 76 (01) :98-102

[5] 3D COMPUTED X-RAY TOMOGRAPHY OF HUMAN CANCELLOUS BONE AT 8 MU-M SPATIAL AND 10(-4) ENERGY RESOLUTION [J].

BONSE, U ;

BUSCH, F ;

GUNNEWIG, O ;

BECKMANN, F ;

PAHL, R ;

DELLING, G ;

HAHN, M ;

GRAEFF, W .

BONE AND MINERAL, 1994, 25 (01) :25-38

[6] Holotomography: Quantitative phase tomography with micrometer resolution using hard synchrotron radiation x rays [J].

Cloetens, P ;

Ludwig, W ;

Baruchel, J ;

Van Dyck, D ;

Van Landuyt, J ;

Guigay, JP ;

Schlenker, M .

APPLIED PHYSICS LETTERS, 1999, 75 (19) :2912-2914

[7]

*DABAX, DABAX LIB

[8] Fabrication of diffraction gratings for hard X-ray phase contrast imaging [J].

David, C. ;

Bruder, J. ;

Rohbeck, T. ;

Gruenzweig, C. ;

Kottler, C. ;

Diaz, A. ;

Bunk, O. ;

Pfeiffer, F. .

MICROELECTRONIC ENGINEERING, 2007, 84 (5-8) :1172-1177

[9] Computed tomography of x-ray index of refraction using the diffraction enhanced imaging method [J].

Dilmanian, FA ;

Zhong, Z ;

Ren, B ;

Wu, XY ;

Chapman, LD ;

Orion, I ;

Thomlinson, WC .

PHYSICS IN MEDICINE AND BIOLOGY, 2000, 45 (04) :933-946

[10] The fractional Talbot effect in differential x-ray phase-contrast imaging for extended and polychromatic x-ray sources [J].

Engelhardt, M. ;

Kottler, C. ;

Bunk, O. ;

David, C. ;

Schroer, C. ;

Baumann, J. ;

Schuster, M. ;

Pfeiffer, F. .

JOURNAL OF MICROSCOPY, 2008, 232 (01) :145-157

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