Quantification of neurometabolites in subacute sclerosing panencephalitis by 1H-MRS

被引：21
作者：
Aydin, K.
Tatli, B.
Ozkan, M.
Ciftci, K.
Unal, Z.
Sani, S.
Ozmen, M.
Caliskan, M.
Aydinli, N.
Guven, S.
机构：
[1] Univ Istanbul, Sch Med, Dept Neuroradiol, Istanbul, Turkey
[2] Univ Istanbul, Sch Med, Dept Pediat Neurol, Istanbul, Turkey
[3] Univ Istanbul, Sch Med, Dept Radiol, Istanbul, Turkey
[4] Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey
[5] VKU Amer Hosp, Dept Radiol, Istanbul, Turkey
[6] Bakirkoy Maternal & Childhood Dis Educ Hosp, Dept Pediat, Istanbul, Turkey
来源：
NEUROLOGY | 2006年 / 67卷 / 05期
关键词：
D O I：
10.1212/01.wnl.0000233836.16266.f5
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors studied 20 patients with subacute sclerosing panencephalitis (SSPE) to investigate the correlations between MRI, magnetic resonance spectroscopy (MRS), and clinical status. MRI findings did not correlate with clinical status. By contrast, all patients had reductions in N-acetyl aspartate (NAA) and increase in myoinositol (mI) (p < 0.01), and NAA and mI concentrations correlated with clinical severity (p < 0.05). During follow-up, NAA continued to decline. H-1-MRS may be a useful measure of disease severity and progression in SSPE.
引用
收藏
页码：911 / 913
页数：3
相关论文
共 10 条
[1]  
Alkan A, 2003, AM J NEURORADIOL, V24, P501
[2]  
Brismar J, 1996, AM J NEURORADIOL, V17, P761
[3]   LONG-TERM FOLLOW-UP OF PATIENTS WITH SUB-ACUTE SCLEROSING PANENCEPHALITIS TREATED WITH INOSIPLEX [J].
DYKEN, PR ;
SWIFT, A ;
DURANT, RH .
ANNALS OF NEUROLOGY, 1982, 11 (04) :359-364
[4]   Subacute sclerosing panencephalitis [J].
Garg, RK .
POSTGRADUATE MEDICAL JOURNAL, 2002, 78 (916) :63-70
[5]  
JABBOUR JT, 1969, J AMER MED ASSOC, V207, P2248
[6]   Absolute metabolite quantification by in vivo NMR spectroscopy:: II.: A multicentre trial of protocols for in vivo localised proton studies of human brain [J].
Keevil, SF ;
Barbiroli, B ;
Brooks, JCW ;
Cady, EB ;
Canese, R ;
Carlier, P ;
Collins, DJ ;
Gilligan, P ;
Gobbi, G ;
Hennig, J ;
Kügel, H ;
Leach, MO ;
Metzler, D ;
Mlynárik, V ;
Moser, E ;
Newbold, MC ;
Payne, GS ;
Ring, P ;
Roberts, JN ;
Rowland, IJ ;
Thiel, T ;
Tkác, I ;
Topp, S ;
Wittsack, HJ ;
Wylezinska, M ;
Zaniol, P ;
Henriksen, O ;
Podo, F .
MAGNETIC RESONANCE IMAGING, 1998, 16 (09) :1093-1106
[7]   LACTATE PRODUCTION BY HUMAN MONOCYTES MACROPHAGES DETERMINED BY PROTON MR SPECTROSCOPY [J].
LOPEZVILLEGAS, D ;
LENKINSKI, RE ;
WEHRLI, SL ;
HO, WZ ;
DOUGLAS, SD .
MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (01) :32-38
[8]   Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis [J].
Michael, N ;
Erfurth, A ;
Lüdemann, P ;
Schuierer, G ;
Möller, HE .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2005, 139 (03) :269-273
[9]   Subacute sclerosing panencephalitis:: Clinical and magnetic resonance Imaging evaluation of 36 patients [J].
Öztürk, A ;
Gürses, C ;
Baykan, B ;
Gökyigit, A ;
Eraksoy, M .
JOURNAL OF CHILD NEUROLOGY, 2002, 17 (01) :25-29
[10]   Interferon therapy-responsive brain metabolic abnormalities in a case of adult-onset subacute sclerosing panencephalitis evaluated by 1H MRS analysis [J].
Takashima, H ;
Eriguchi, M ;
Nakamura, T ;
Satoh, J ;
Kuroda, Y ;
Udono, H ;
Uchino, A .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2003, 207 (1-2) :59-63
1