Do BACE inhibitor failures in Alzheimer patients challenge the amyloid hypothesis of the disease?

被引：29

作者：

Panza, Francesco ^{[1
,2
]}

Lozupone, Madia ^{[3
]}

Watling, Mark ^{[4
]}

Imbimbo, Bruno Pietro ^{[4
]}

机构：

[1] IRCCS S De Bellis Castellana Grotte, Natl Inst Gastroenterol, Unit Epidemiol Res Aging, Bari, Italy

[2] IRCCS S De Bellis Castellana Grotte, Res Hosp, Bari, Italy

[3] Univ Bari Aldo Moro, Dept Basic Med, Neurodegenerat Dis Unit, Neurosci & Sense Organs, Bari, Italy

[4] Chiesi Farmaceut, Dept Res & Dev, Parma, Italy

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2019年 / 19卷 / 07期

关键词：

BACE inhibitors; dementia; cognitive disorders; Alzheimer's disease; MCI; lifestyle; SYNAPTIC PLASTICITY; PHYSIOLOGICAL-ROLE; RANDOMIZED-TRIAL; BETA PEPTIDE; MUTATIONS;

D O I：

10.1080/14737175.2019.1621751

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

引用

页码：599 / 602

页数：4

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