Aromatic sialic acid analogues as potential inhibitors of influenza virus neuraminidase

被引：7
|
作者：
Bianco, A
Brufani, M
Melchioni, C
机构：
[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy
[2] Univ Roma La Sapienza, Dipartimento Sci Biochim, Rome, Italy
来源：
FARMACO | 2001年 / 56卷 / 04期
关键词：
sialic acid; influenza; neuraminidase;
D O I：
10.1016/S0014-827X(01)01081-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The influenza virus neuraminidase (NA) is an enzyme essential for viral infection and offers a potential target for antiviral drug development. We aimed our research at the synthesis of non-carbohydrate molecules able to inhibit NA as transition-state analogues. Aromatic sialic acid analogues (compound 5 and compound 10) were synthesised in good yields starting from commercially available benzoic acids using a suitable synthetic strategy. (C) 2001 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：305 / 309
页数：5
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