Poor prognostic factors guiding treatment decisions in rheumatoid arthritis patients: a review of data from randomized clinical trials and cohort studies

被引：71

作者：

Albrecht, Katinka ^{[1
]}

Zink, Angela ^{[1
,2
]}

机构：

[1] German Rheumatism Res Ctr, Epidemiol Unit, Charitepl 1, D-10117 Berlin, Germany

[2] Charite, Rheumatol & Clin Immunol, D-13353 Berlin, Germany

来源：

ARTHRITIS RESEARCH & THERAPY | 2017年 / 19卷

关键词：

Rheumatoid arthritis; Prognostic factors; Treatment; Outcome; RAPID RADIOGRAPHIC PROGRESSION; MODIFYING ANTIRHEUMATIC DRUGS; DISEASE-ACTIVITY; TREATMENT RESPONSE; DOUBLE-BLIND; RISK MODEL; RECOMMENDATIONS; REMISSION; SOCIETY; UPDATE;

D O I：

10.1186/s13075-017-1266-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prognostic factors are used for treatment decisions in rheumatoid arthritis ( RA). High disease activity, the early presence of erosions, and autoantibody positivity are the most frequently used poor prognostic factors but other features, such as functional disability, extraarticular disease, or multibiomarkers, are also assessed. Prognostic factors are incorporated in current treatment recommendations for the management of RA and are used as inclusion criteria in randomized controlled trials. They are defined heterogeneously and the relevance of a single or combined presence of poor prognostic factors remains unclear. This review summarizes the current definitions of poor prognostic factors and their use in clinical research. Perspectives on future research are also outlined.

引用

页数：8

共 46 条

[31] Biomarkers to guide clinical therapeutics in rheumatology? [J].

Robinson, William H. ;

Mao, Rong .

CURRENT OPINION IN RHEUMATOLOGY, 2016, 28 (02) :168-175

[32] Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritis: results from the SWEFOT trial [J].

Saevarsdottir, Saedis ;

Rezaei, Hamed ;

Geborek, Pierre ;

Petersson, Ingemar ;

Ernestam, Sofia ;

Albertsson, Kristina ;

Forslind, Kristina ;

van Vollenhoven, Ronald F. .

ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 (08) :1509-1514

[33] Predictors of response to methotrexate in early DMARD naive rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial [J].

Saevarsdottir, Saedis ;

Wallin, Helena ;

Seddighzadeh, Maria ;

Ernestam, Sofi A. ;

Geborek, Pierre ;

Petersson, Ingemar F. ;

Bratt, Johan ;

van Vollenhoven, Ronald F. .

ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (03) :469-475

[34]

Sanmartí R, 2015, REUMATOL CLIN, V11, P279, DOI [10.1016/J.REUMA.2015.05.001, 10.1016/j.reuma.2015.05.001]

[35] Differences in Predictive Factors for Sustained Clinical Remission with Abatacept Between Younger and Elderly Patients with Biologic-naive Rheumatoid Arthritis: Results from the ABROAD Study [J].

Sekiguchi, Masahiro ;

Fujii, Takao ;

Matsui, Kiyoshi ;

Murakami, Kosaku ;

Morita, Satoshi ;

Ohmura, Koichiro ;

Kawahito, Yutaka ;

Nishimoto, Norihiro ;

Mimori, Tsuneyo ;

Sano, Hajime .

JOURNAL OF RHEUMATOLOGY, 2016, 43 (11) :1974-1983

[36] THE PROGRESSION OF EROSION AND JOINT SPACE NARROWING SCORES IN RHEUMATOID-ARTHRITIS DURING THE 1ST 25 YEARS OF DISEASE [J].

SHARP, JT ;

WOLFE, F ;

MITCHELL, DM ;

BLOCH, DA .

ARTHRITIS AND RHEUMATISM, 1991, 34 (06) :660-668

[37]

Singh JA, 2016, ARTHRITIS RHEUMATOL, V68, P1, DOI 10.1002/art.39480

[38] 2012 Update of the 2008 American College of Rheumatology Recommendations for the Use of Disease-Modifying Antirheumatic Drugs and Biologic Agents in the Treatment of Rheumatoid Arthritis [J].

Singh, Jasvinder A. ;

Furst, Daniel E. ;

Bharat, Aseem ;

Curtis, Jeffrey R. ;

Kavanaugh, Arthur F. ;

Kremer, Joel M. ;

Moreland, Larry W. ;

O'Dell, James ;

Winthrop, Kevin L. ;

Beukelman, Timothy ;

Bridges, S. Louis, Jr. ;

Chatham, W. Winn ;

Paulus, Harold E. ;

Suarez-Almazor, Maria ;

Bombardier, Claire ;

Dougados, Maxime ;

Khanna, Dinesh ;

King, Charles M. ;

Leong, Amye L. ;

Matteson, Eric L. ;

Schousboe, John T. ;

Moynihan, Eileen ;

Kolba, Karen S. ;

Jain, Archana ;

Volkmann, Elizabeth R. ;

Agrawal, Harsh ;

Bae, Sangmee ;

Mudano, Amy S. ;

Patkar, Nivedita M. ;

Saag, Kenneth G. .

ARTHRITIS CARE & RESEARCH, 2012, 64 (05) :625-639

[39] EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update [J].

Smolen, Josef S. ;

Landewe, Robert ;

Breedveld, Ferdinand C. ;

Buch, Maya ;

Burmester, Gerd ;

Dougados, Maxime ;

Emery, Paul ;

Gaujoux-Viala, Cecile ;

Gossec, Laure ;

Nam, Jackie ;

Ramiro, Sofia ;

Winthrop, Kevin ;

de Wit, Maarten ;

Aletaha, Daniel ;

Betteridge, Neil ;

Bijlsma, Johannes W. J. ;

Boers, Maarten ;

Buttgereit, Frank ;

Combe, Bernard ;

Cutolo, Maurizio ;

Damjanov, Nemanja ;

Hazes, Johanna M. W. ;

Kouloumas, Marios ;

Kvien, Tore K. ;

Mariette, Xavier ;

Pavelka, Karel ;

van Riel, Piet L. C. M. ;

Rubbert-Roth, Andrea ;

Scholte-Voshaar, Marieke ;

Scott, David L. ;

Sokka-Isler, Tuulikki ;

Wong, John B. ;

van der Heijde, Desiree .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (03) :492-509

[40] Quantitative power Doppler ultrasound measures of peripheral joint synovitis in poor prognosis early rheumatoid arthritis predict radiographic progression [J].

Sreerangaiah, Dee ;

Grayer, Michael ;

Fisher, Benjamin A. ;

Ho, Meilien ;

Abraham, Sonya ;

Taylor, Peter C. .

RHEUMATOLOGY, 2016, 55 (01) :89-93

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