Poor prognostic factors guiding treatment decisions in rheumatoid arthritis patients: a review of data from randomized clinical trials and cohort studies

被引：71

作者：

Albrecht, Katinka ^{[1
]}

Zink, Angela ^{[1
,2
]}

机构：

[1] German Rheumatism Res Ctr, Epidemiol Unit, Charitepl 1, D-10117 Berlin, Germany

[2] Charite, Rheumatol & Clin Immunol, D-13353 Berlin, Germany

来源：

ARTHRITIS RESEARCH & THERAPY | 2017年 / 19卷

关键词：

Rheumatoid arthritis; Prognostic factors; Treatment; Outcome; RAPID RADIOGRAPHIC PROGRESSION; MODIFYING ANTIRHEUMATIC DRUGS; DISEASE-ACTIVITY; TREATMENT RESPONSE; DOUBLE-BLIND; RISK MODEL; RECOMMENDATIONS; REMISSION; SOCIETY; UPDATE;

D O I：

10.1186/s13075-017-1266-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prognostic factors are used for treatment decisions in rheumatoid arthritis ( RA). High disease activity, the early presence of erosions, and autoantibody positivity are the most frequently used poor prognostic factors but other features, such as functional disability, extraarticular disease, or multibiomarkers, are also assessed. Prognostic factors are incorporated in current treatment recommendations for the management of RA and are used as inclusion criteria in randomized controlled trials. They are defined heterogeneously and the relevance of a single or combined presence of poor prognostic factors remains unclear. This review summarizes the current definitions of poor prognostic factors and their use in clinical research. Perspectives on future research are also outlined.

引用

页数：8

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