Synthesis and Properties of a Polymerizable Quaternary Ammonium Salt

Novel polymerizable monomer N, N-dimethyl-2-[(2-methylacryloyl) oxy] ethanaminium 5-carboxy-2,4-bis benzoate (DMAEMA-PMDPM salt) was synthesized by acid-alkali neutralizing reaction and was proved to be successful by Fourier transform infrared spectroscopy. The antibacterial activity and cytotoxicity of monomer were assessed by determination of the minimal inhibitory concentration and minimal bactericidal concentration, time-kill study and methyltetrazolium test assay. Polymerizable efficiency was determined by measurement of degree of conversion. The results indicated that DMAEMA-PMDPM salt which is a kind of liquid polymerizable has some antimicrobial activity and similar cytotoxicity to common dental resin monomers. The new monomer also has a high polymerizable ability. Therefore it might have a great potential to prepare antimicrobial coatings on denture base and soft lining materials, as well as some biomedical applications. (C) 2014 Wiley Periodicals, Inc.