Mammary Tumorigenesis through LPA Receptor Signaling

被引：28

作者：

Jonkers, Jos ^{[2
]}

Moolenaar, Wouter H. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands

来源：

CANCER CELL | 2009年 / 15卷 / 06期

关键词：

LYSOPHOSPHATIDIC ACID; CANCER;

D O I：

10.1016/j.ccr.2009.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors. In this issue of Cancer Cell, Liu et al. show that transgenic overexpression of ATX or LPA receptors leads to invasive and metastatic mammary cancer.

引用

页码：457 / 459

页数：3

共 10 条

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