A lactam-derived vinyl boronate as a stable and crystalline reagent for the synthesis of 2--substituted piperidines by Pd-catalyzed coupling reactions

被引：9

作者：

Ferrali, A ^{[1
]}

Guarna, A ^{[1
]}

Lo Galbo, F ^{[1
]}

Occhiato, EG ^{[1
]}

机构：

[1] Univ Florence, Dipartimento Chim Organ U Schiff, I-50019 Sesto Fiorentino, Italy

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 27期

关键词：

D O I：

10.1016/j.tetlet.2004.05.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A delta-valerolactam-derived vinyl triflate has been converted into the corresponding vinyl boronate by Pd-catalyzed coupling with bis(pinacolato)diboron, which results in all umpolung. This boronate efficiently couples under Pd catalysis with aryl and heteroaryl bromides to give the corresponding 2-substituted piperidines ill excellent yields. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5271 / 5274

页数：4

共 45 条

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