EPICARDIAL TRANSPLANTATION OF CARDIAC PROGENITOR CELLS BASED CELLS SHEETS IS MORE PROMISING METHOD FOR STIMULATION OF MYOCARDIAL REGENERATION, THAN CONVENTIONAL CELL INJECTIONS

被引：4
作者：
Dergilev, K., V [1 ]
Tsokolayeva, Z., I [1 ]
Beloglazova, I. B. [1 ]
Ratner, E., I [1 ]
Parfyonova, E., V [1 ,2 ]
机构：
[1] Natl Med Res Ctr Cardiol, Moscow, Russia
[2] Lomonosov Moscow State Univ, Moscow, Russia
来源：
KARDIOLOGIYA | 2019年 / 59卷 / 05期
关键词：
cardiac progenitor cells; myocardial infarction; vascularization; cell sheet; STEM-CELLS; INFARCTION; REPAIR; CARDIOMYOCYTES; ANGIOGENESIS; SKELETAL;
D O I：
10.18087/cardio.2019.5.2597
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Today, transplantation of stem/progenitor cells is a promising approach for the treatment of heart diseases. The therapeutic potential of transplanted cells directly depends on the method of delivery to the myocardium, which determines their regenerative properties. It is important for the development of effective methods of cell therapy. In this paper, we performed a comparative study of efficacy of cardiac progenitor cell (CPC) transplantation by intramyocardial needle injections and by tissue engineering constructs (TEC) - "cell sheets" consisting of cells and their extracellular matrix. It has been shown, that transplantation of TEC in comparison with the intramyocardial delivery provides more extensive distribution and retains more proliferating cellular elements in the damaged myocardium, attenuates the negative cardiac remodeling of the left ventricle and promotes its vascularization.
引用
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页码：53 / 60
页数：8
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