Dermatomyositis Clinical and Pathological Phenotypes Associated with Myositis-Specific Autoantibodies

被引:75
作者
Wolstencroft, Paige W. [1 ]
Fiorentino, David F. [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Dermatol, 450 Broadway St, Redwood City, CA 94063 USA
关键词
Dermatomyositis; Myositis-specific autoantibodies; MSAs; Autoimmune disease; Autoantibodies; INTERSTITIAL LUNG-DISEASE; IDIOPATHIC INFLAMMATORY MYOPATHIES; MODIFIER ACTIVATING ENZYME; JAPANESE PATIENTS; JUVENILE DERMATOMYOSITIS; ANTI-MI-2; AUTOANTIBODIES; ANTI-SAE; ANTIBODIES; PROTEIN; IDENTIFICATION;
D O I
10.1007/s11926-018-0733-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Dermatomyositis is an idiopathic inflammatory myopathy with a variety of systemic and cutaneous manifestations. The myositis-specific autoantibodies (MSAs) are associated with phenotypic features and provide a tool for subclassification of dermatomyositis patients. This review focuses on recent work characterizing the clinical features that accompany the MSAs in dermatomyositis. Recent findings There is increasing recognition of the distinct clinical and pathological phenotypes associated with each MSA. Most of these features display considerable overlap between MSA groups. Despite this, there are notable differences between the typical combinations of cutaneous and systemic manifestations, response to therapy, prognosis, and disease sequelae that define each dermatomyositis MSA group. Summary The MSAs may ultimately improve diagnosis and sub-classification of dermatomyositis patients. However, more work is needed to understand the pathologic basis for much of the heterogeneity found within these subgroups.
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页数:11
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