Structure Activity Studies on the Crinane Alkaloid Apoptosis-inducing Pharmacophore

被引：0

作者：

McNulty, James ^{[1
]}

Nair, Jerald J. ^{[1
]}

Bastida, Jaume ^{[2
]}

Pandey, Siyaram ^{[3
]}

Griffin, Carly ^{[3
]}

机构：

[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada

[2] Univ Barcelona, Fac Farm, Dept Nat Prod, E-08028 Barcelona, Spain

[3] Univ Windsor, Dept Chem & Biochem, Windsor, ON N9B 3P4, Canada

来源：

NATURAL PRODUCT COMMUNICATIONS | 2009年 / 4卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Alkaloid; Amaryllidaceae; Crinane; Apoptosis; Cytotoxicity; SOUTH-AFRICAN AMARYLLIDACEAE; PANCRATISTATIN; HYMENOCALLIS; REFINEMENT; INHIBITORS; PLANTS; BULBS; CELLS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The apoptosis-inducing ability of alpha-ethano bridged crinane alkaloids was investigated using natural and semi-synthetic derivatives uncovering novel structural requirements of this cytotoxic pharmacophore. An alpha-ethano bridge is required; an alpha- or beta-methoxy or hydroxyl H-bond acceptor are all tolerated at C-3; a small substituent (H, or OH) alone is tolerated at C-11; and a C-1 to C-2 double bond is shown to modulate, but is not a requirement for, apoptosis-inducing activity.

引用

页码：483 / 488

页数：6

共 50 条

[21] Antioxidant and apoptosis-inducing actiities of ellagic acid
Han, Dong Hoon
Lee, Min Jeon
Kim, Jeong Hee
ANTICANCER RESEARCH, 2006, 26 (5A) : 3601 - 3606
[22] Relationship between ascorbyl radical intensity and apoptosis-inducing activity
Sakagami, H
Satoh, K
Ohata, H
Takahashi, H
Yoshida, H
Iida, M
Kuribayashi, N
Sakagami, T
Momose, K
Takeda, M
ANTICANCER RESEARCH, 1996, 16 (5A) : 2635 - 2644
[23] Synthesis of Oxovanadium Complexes and Their Apoptosis-Inducing Activity in Leukemia Cells
Yamaguchi, Tomoko
Watanabe, Shinya
Matsumura, Yuriko
Tokuoka, Yoshikazu
Yokoyama, Akihiro
CHEMICAL & PHARMACEUTICAL BULLETIN, 2012, 60 (04) : 508 - 512
[24] Structure and function of bak gene and its apoptosis-inducing mechanism
Li, Y
Qi, YP
Xiao, GF
CHINESE SCIENCE BULLETIN, 1999, 44 (07): : 605 - 609
[25] Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis
Cheung, Eric C. C.
Joza, Nicholas
Steenaart, Nancy A. E.
McClellan, Kelly A.
Neuspiel, Margaret
McNamara, Stephen
MacLaurin, Jason G.
Rippstein, Peter
Park, David S.
Shore, Gordon C.
McBride, Heidi M.
Penninger, Josef M.
Slack, Ruth S.
EMBO JOURNAL, 2006, 25 (17): : 4061 - 4073
[26] Structure and function of bak gene and its apoptosis-inducing mechanism
LI Yan
ChineseScienceBulletin, 1999, (07) : 605 - 609
[27] Synthesis and Biological Evaluation of Styrylheterocycles Analogs of Resveratrol as Apoptosis-Inducing Agents
Antonioletti, Roberto
Righi, Giuliana
Ricelli, Alessandra
Rossetti, Ilaria
Viglianti, Angela
Frezza, Caterina
Marino-Merlo, Francesca
Macchi, Beatrice
CURRENT ORGANIC CHEMISTRY, 2017, 21 (10) : 939 - 948
[28] Dipterocarpol in Oleoresin of Dipterocarpus alatus Attributed to Cytotoxicity and Apoptosis-Inducing Effect
Puthongking, Ploenthip
Yongram, Chawalit
Katekaew, Somporn
Sungthong, Bunleu
Weerapreeyakul, Natthida
MOLECULES, 2022, 27 (10):
[29] Synthesis and antiproliferative and apoptosis-inducing activity of novel 3-substituted-3-hydroxy-2-oxindole compounds
Moghaddam, Mona Nazemi
Jalal, Razieh
Zeraatkar, Zohreh
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2018, 54 (01) : 61 - 70
[30] Novel Naphthalimide-Benzoic Acid Conjugates as Potential Apoptosis-Inducing Agents: Design, Synthesis, and Biological Activity
Wu, Aibin
Mei, Ping
Xu, Yufang
Qian, Xuhong
CHEMICAL BIOLOGY & DRUG DESIGN, 2011, 78 (06) : 941 - 947

← 1 2 3 4 5 →