Structure Activity Studies on the Crinane Alkaloid Apoptosis-inducing Pharmacophore

被引：0

作者：

McNulty, James ^{[1
]}

Nair, Jerald J. ^{[1
]}

Bastida, Jaume ^{[2
]}

Pandey, Siyaram ^{[3
]}

Griffin, Carly ^{[3
]}

机构：

[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada

[2] Univ Barcelona, Fac Farm, Dept Nat Prod, E-08028 Barcelona, Spain

[3] Univ Windsor, Dept Chem & Biochem, Windsor, ON N9B 3P4, Canada

来源：

NATURAL PRODUCT COMMUNICATIONS | 2009年 / 4卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Alkaloid; Amaryllidaceae; Crinane; Apoptosis; Cytotoxicity; SOUTH-AFRICAN AMARYLLIDACEAE; PANCRATISTATIN; HYMENOCALLIS; REFINEMENT; INHIBITORS; PLANTS; BULBS; CELLS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The apoptosis-inducing ability of alpha-ethano bridged crinane alkaloids was investigated using natural and semi-synthetic derivatives uncovering novel structural requirements of this cytotoxic pharmacophore. An alpha-ethano bridge is required; an alpha- or beta-methoxy or hydroxyl H-bond acceptor are all tolerated at C-3; a small substituent (H, or OH) alone is tolerated at C-11; and a C-1 to C-2 double bond is shown to modulate, but is not a requirement for, apoptosis-inducing activity.

引用

页码：483 / 488

页数：6

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