Complement activation in patients with COVID-19: A novel therapeutic target

被引：197

作者：

Cugno, Massimo ^{[1
,2
]}

Meroni, Pier Luigi ^{[3
]}

Gualtierotti, Roberta ^{[1
,2
]}

Griffini, Samantha ^{[1
,2
]}

Grovetti, Elena ^{[1
,2
]}

Torri, Adriana ^{[2
]}

Panigada, Mauro ^{[4
,5
]}

Aliberti, Stefano ^{[1
,5
]}

Blasi, Francesco ^{[1
,5
]}

Tedesco, Francesco ^{[3
]}

Peyvandi, Flora ^{[1
,2
]}

机构：

[1] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy

[2] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr, Milan, Italy

[3] IRCCS Ist Auxol Italiano, Immunorheumatol Res Lab, Milan, Italy

[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, UOC Anestesia & Terapia Intens Adulti, Milan, Italy

[5] Fdn IRCCS Ca Granda Osped Maggiore Policlin, UOC Pneumol, Milan, Italy

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2020年 / 146卷 / 01期

关键词：

D O I：

10.1016/j.jaci.2020.05.006

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：215 / +

页数：4

共 9 条

[1] HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN EXERTS ITS BENEFICIAL EFFECT IN PATIENTS WITH DERMATOMYOSITIS BY BLOCKING ENDOMYSIAL DEPOSITION OF ACTIVATED COMPLEMENT FRAGMENTS
BASTA, M
DALAKAS, MC
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (05) : 1729 - 1735
[2] Clinical and immunological features of severe and moderate coronavirus disease 2019
Chen, Guang
Wu, Di
Guo, Wei
Cao, Yong
Huang, Da
Wang, Hongwu
Wang, Tao
Zhang, Xiaoyun
Chen, Huilong
Yu, Haijing
Zhang, Xiaoping
Zhang, Minxia
Wu, Shiji
Song, Jianxin
Chen, Tao
Han, Meifang
Li, Shusheng
Luo, Xiaoping
Zhao, Jianping
Ning, Qin
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (05) : 2620 - 2629
[3] Diao B., 2020, 20032524 MEDRXIV, DOI [10.1101, 10.1101/2020.03.04.20031120]
[4] Gao T., 2020, HIGHLY PATHOGENIC CO, DOI [DOI 10.1101/2020.03.29.20041962, 10.1101/2020.03.29.20041962]
[5] Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis
Gralinski, Lisa E.
Sheahan, Timothy P.
Morrison, Thomas E.
Menachery, Vineet D.
Jensen, Kara
Leist, Sarah R.
Whitmore, Alan
Heise, Mark T.
Baric, Ralph S.
[J]. MBIO, 2018, 9 (05):
[6] Guan WJ, 2020, NEW ENGL J MED, V382, P1861, DOI 10.1056/NEJMc2005203
[7] Eculizumab and Beyond: The Past, Present, and Future of Complement Therapeutics
Patriquin, Christopher J.
Kuo, Kevin H. M.
[J]. TRANSFUSION MEDICINE REVIEWS, 2019, 33 (04) : 256 - 265
[8] Spectrum of Complement-Mediated Thrombotic Microangiopathies: Pathogenetic Insights Identifying Novel Treatment Approaches
Riedl, Magdalena
Fakhouri, Fadi
Le Quintrec, Moglie
Noone, Damien G.
Jungraithmayr, Therese C.
Fremeaux-Bacchi, Veronique
Licht, Christoph
[J]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2014, 40 (04) : 444 - 464
[9] Endothelial cell infection and endotheliitis in COVID-19
Varga, Zsuzsanna
Flammer, Andreas J.
Steiger, Peter
Haberecker, Martina
Andermatt, Rea
Zinkernagel, Annelies S.
Mehra, Mandeep R.
Schuepbach, Reto A.
Ruschitzka, Frank
Moch, Holger
[J]. LANCET, 2020, 395 (10234) : 1417 - 1418

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