Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies

被引：44

作者：

Feng, Yuanyuan ^{[1
]}

Zhou, Lihong ^{[1
]}

Sun, Xiaoting ^{[1
]}

Li, Qi ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Med Oncol, Shanghai, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 12期

基金：

中国国家自然科学基金;

关键词：

HIPK2; cancer; p53; apoptosis; angiogenesis; DNA-DAMAGE; CANCER-CELLS; P53; ACTIVITY; C-MYB; HOMEODOMAIN-INTERACTING-PROTEIN-KINASE-2; HIPK2; P53SER46; PHOSPHORYLATION; TRANSCRIPTION FACTORS; PROMOTES APOPTOSIS; COLORECTAL-CANCER; UBIQUITIN LIGASE;

D O I：

10.18632/oncotarget.14723

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a "caretaker" gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angiogenesis in hypoxia, prevention of tumor invasion/metastasis and attenuation of multidrug resistance in cancer. Additionally, we summarize conditions or factors that may increase HIPK2 activity.

引用

页码：20452 / 20461

页数：10

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