Oxysterols and symptomatic versus asymptomatic human atherosclerotic plaque

被引:26
作者
Khatib, Soliman
Vaya, Jacob
机构
[1] MIGAL Galilee Res Inst, Dept Oxidat Stress & Human Dis, IL-11016 Kiryat Shmona, Israel
[2] Tel Hai Coll, IL-12210 Upper Galilee, Israel
关键词
Asymptomatic; Atherosclerosis; Oxysterols; Plaque; Symptomatic; LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; OXIDIZED LIPIDS; CAROTID PLAQUES; STEROL; 27-HYDROXYLASE; DIETARY-CHOLESTEROL; INDUCED APOPTOSIS; OXIDATION; RUPTURE; 7-BETA-HYDROXYCHOLESTEROL;
D O I
10.1016/j.bbrc.2013.12.116
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Atherosclerosis is the most common cause of mortality in the Western world, contributing to about 50% of all deaths. Atherosclerosis is characterized by deposition of lipids onto the coronary or carotid arterial wall and formation of an atherosclerotic plaque. Atherosclerotic plaques are categorized into two groups: symptomatic and asymptomatic. The symptomatic plaques tend to be unstable and prone to rupture, and are associated with an increase in ischemic events. Oxysterols, products of cholesterol oxidation, are cytotoxic materials. Their level and type may be associated with plaque formation, development and stability. Oxysterols stimulate the formation of foam cells, advance atherosclerotic plaque progression, and contribute to plaque vulnerability and instability due to their cytotoxicity and their ability to induce cell apoptosis. Studies indicate that plasma 7 beta-OH CH level can be used as a biomarker for detecting carotid and coronary artery disease. Further clinical studies are needed to evaluate the potential of oxysterols for use as biomarkers for plaque vulnerability and instability. The identification of biomarkers in the blood that can distinguish between symptomatic and asymptomatic plaques remains an unresolved issue. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:709 / 713
页数:5
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