Preparation of 4,5 disubstituted-2H-1,2,3-triazoles from (Z)-2,3-diaryl substituted acrylonitriles

被引：11

作者：

Madadi, Nikhil Reddy ^{[1
]}

Penthala, Narsimha Reddy ^{[1
]}

Song, Lin ^{[1
]}

Hendrickson, Howard P. ^{[1
]}

Crooks, Peter A. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Coll Pharm, Dept Pharmaceut Sci, Little Rock, AR 72205 USA

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 30期

关键词：

Sodium azide; Triazole synthesis; Acrylonitrile; Huisgen cycloaddition; ANALOGS; AGENTS;

D O I：

10.1016/j.tetlet.2014.05.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2H-1,2,3-Triazoles (2) were synthesized by [3+2] cycloaddition of (Z)-2,3-diaryl substituted acrylonitriles (1) with sodium azide and ammonium chloride in DMF/water. This method represents a facile and efficient reaction procedure for the synthesis of 4,5-diary1-2H-1,2,3-triazoles in modest to good yields. (C) 2014 Elsevier Ltd. All rights reserved.

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页码：4207 / 4211

页数：5

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