Preclinical research on pain comorbidity with affective disorders and cognitive deficits: Challenges and perspectives

被引:76
作者
Liu, Ming-Gang [1 ,2 ,5 ]
Chen, Jun [1 ,2 ,3 ,4 ]
机构
[1] Fourth Mil Med Univ, Tangdu Hosp, Inst Biomed Sci Pain, Xian 710038, Peoples R China
[2] Fourth Mil Med Univ, Tangdu Hosp, Inst Funct Brain Disorders, Xian 710038, Peoples R China
[3] PLA, Key Lab Brain Stress & Behav, Xian 710038, Peoples R China
[4] Beijing Inst Brain Disorders, Beijing 100069, Peoples R China
[5] Seoul Natl Univ, Dept Brain & Cognit Sci, Coll Nat Sci, Seoul 151746, South Korea
关键词
Chronic pain; Comorbidity; Emotional disorder; Cognitive impairment; Synaptic plasticity; Animals; ANTERIOR CINGULATE CORTEX; HIPPOCAMPAL SYNAPTIC PLASTICITY; LONG-TERM POTENTIATION; STREPTOZOTOCIN-DIABETIC RATS; PERIPHERAL-NERVE INJURY; ANXIETY-LIKE BEHAVIOR; PRIMARY SOMATOSENSORY CORTEX; ELEVATED PLUS-MAZE; NEUROPATHIC PAIN; MULTIELECTRODE ARRAY;
D O I
10.1016/j.pneurobio.2014.01.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Affective disorders and cognitive deficits are common comorbidities of chronic pain in the clinical setting, which severely affect the quality of life of pain patients and impose a great difficulty upon clinical pain therapy. Despite large numbers of human studies examining this issue, there are surprisingly few reports investigating the comorbidities of chronic pain in animal models. This review summarizes and integrates previous reports of animal studies on pain and comorbidity, covering pain-evoked anxiety, depression, attentional deficits, cognitive impairment and locomotor dysfunction in rodents. Moreover, pain-induced alterations in synaptic plasticity are also discussed in terms of long-term potentiation and long-term depression, synaptic transmission, neuronal excitability and structural correlates in 'pain matrix'. Finally, we conclude this review by pointing out some unresolved problems and future research directions. (c) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:13 / 32
页数:20
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