Investigation of inclusion complex of Epothilone A with cyclodextrins

被引：44

作者：

Xiao, Chuan-Fan ^{[1
]}

Li, Ke ^{[2
]}

Huang, Rong ^{[1
]}

He, Guo-Jin ^{[1
]}

Zhang, Jian-Qiang ^{[1
]}

Zhu, Li ^{[1
]}

Yang, Qing-Yi ^{[1
]}

Jiang, Kun-Ming ^{[1
]}

Jin, Yi ^{[1
]}

Lin, Jun ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China

[2] Kunming Med Univ, Affiliated Hosp 3, Dept Med Oncol 1, Kunming 650031, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2014年 / 102卷

基金：

中国国家自然科学基金;

关键词：

Epothilone A; Cyclodextrin; Inclusion complex; Characterization; Inclusion mode; HOST-GUEST SYSTEM; COLORIMETRIC ASSAY; MODE;

D O I：

10.1016/j.carbpol.2013.11.049

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The inclusion complexation of Epothilone A with native cyclodextrin (beta- or gamma-CD) and its derivative hydroxypropyl-beta-cyclodextrin (HP beta CD) were prepared. Their behavior, characterization, and binding ability were investigated in both solution and the solid state by means of UV-vis, NMR, XRD, DSC and SEM. The results show that the water solubility and solution stability obviously increased in the inclusion complex with cyclodextrins. Meanwhile, the inclusion complexes still retained anticancer activity against A549 and MCF-7 cells, similar to free Epothilone A. This satisfactory water solubility, high solution stability, and high anticancer activity of the Epothilone A/CD complexes will be potentially useful as an anticancer therapy. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：297 / 305

页数：9

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