Serotonin-2A receptor polymorphism (102T/C) in mood disorders

被引：41
|
作者：
Tsai, SJ
Hong, CJ
Hsu, CC
Cheng, CY
Liao, WY
Song, HL
Lai, HC
机构：
[1] Vet Gen Hosp Taipei, Dept Psychiat, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan
[3] Tao Yuan Vet Hosp, Taipei, Taiwan
来源：
PSYCHIATRY RESEARCH | 1999年 / 87卷 / 2-3期
关键词：
genetics; association study; polymorphism; 5HT(2A) receptor; mood disorders; suicide;
D O I：
10.1016/S0165-1781(99)00059-1
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Serotonergic dysfunction has been implicated in mood disorders and suicidal behaviors. This study examined the association between a serotonin-2A (5HT(2A)) receptor gene polymorphism (102T/C) and mood disorders. The genotype and allele frequencies did not differ between patients with mood disorders and control subjects. Furthermore, the 102T/C polymorphism was not found to be associated with suicidal history in mood disorder patients. Our results suggest that this polymorphism is unlikely to play a role in the genetic susceptibility to mood disorders. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：233 / 237
页数：5
相关论文
共 50 条
  • [41] 102T/C SNP in the 5-hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia in two southern Han Chinese populations:: Lack of association
    Zhang, XN
    Jiang, SD
    He, XH
    Zhang, LN
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 126B (01): : 16 - 18
  • [42] Homocysteine and MTHFR C677T polymorphism in children and adolescents with psychotic and mood disorders
    Kevere, Laura
    Purvina, Santa
    Bauze, Daiga
    Zeibarts, Marcis
    Andrezina, Raisa
    Piekuse, Linda
    Brekis, Edgars
    Purvins, Indulis
    NORDIC JOURNAL OF PSYCHIATRY, 2014, 68 (02) : 129 - 136
  • [43] Association study of the 5-HT2A receptor gene polymorphism, T102C and essential hypertension
    D Liolitsa
    JF Powell
    M Prince
    S Lovestone
    Journal of Human Hypertension, 2001, 15 : 335 - 339
  • [44] Association study of the 5-HT2A receptor gene polymorphism, T102C and essential hypertension
    Liolitsa, D
    Powell, JF
    Prince, M
    Lovestone, S
    JOURNAL OF HUMAN HYPERTENSION, 2001, 15 (05) : 335 - 339
  • [45] T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction
    Mutlu, N
    Erdal, ME
    Herken, H
    Oz, G
    Bayazit, YA
    ORAL DISEASES, 2004, 10 (06) : 349 - 352
  • [46] T3111C CLOCK SINGLE NUCLEOTIDE POLYMORPHISM AND MOOD DISORDERS: A META-ANALYSIS
    Calati, Raffaella
    Gaspar-Barba, Enrique
    Yukler, Adina
    Serretti, Alessandro
    CHRONOBIOLOGY INTERNATIONAL, 2010, 27 (04) : 706 - 721
  • [47] Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder
    Levitan, RD
    Masellis, M
    Basile, VS
    Lam, RW
    Jain, U
    Kaplan, AS
    Kennedy, SH
    Siegel, G
    Walker, ML
    Vaccarino, FJ
    Kennedy, JL
    JOURNAL OF AFFECTIVE DISORDERS, 2002, 71 (1-3) : 229 - 233
  • [48] Association of T102C polymorphism of the 5-HT2A receptor gene with pyschiatric status in fibromyalgia syndrome
    Gürsoy, S
    Erdal, E
    Herken, H
    Madenci, E
    Alasehirli, B
    RHEUMATOLOGY INTERNATIONAL, 2001, 21 (02) : 58 - 61
  • [49] Analysis of the 5HT-2A T102C receptor polymorphism and psychotic symptoms in Alzheimer's disease
    Craig, David
    Donnelly, Caroline
    Hart, Dominic
    Carson, Robyn
    Passmore, Peter
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2007, 144B (01) : 126 - 128
  • [50] Negative association between T102C polymorphism of the 5-HT2a receptor gene and schizophrenia in Japan
    Shinkai, T
    Ohmori, O
    Kojima, H
    Terao, T
    Suzuki, T
    Abe, K
    HUMAN HEREDITY, 1998, 48 (04) : 212 - 215
12345