Serotonin-2A receptor polymorphism (102T/C) in mood disorders

被引：41
|
作者：
Tsai, SJ
Hong, CJ
Hsu, CC
Cheng, CY
Liao, WY
Song, HL
Lai, HC
机构：
[1] Vet Gen Hosp Taipei, Dept Psychiat, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan
[3] Tao Yuan Vet Hosp, Taipei, Taiwan
来源：
PSYCHIATRY RESEARCH | 1999年 / 87卷 / 2-3期
关键词：
genetics; association study; polymorphism; 5HT(2A) receptor; mood disorders; suicide;
D O I：
10.1016/S0165-1781(99)00059-1
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Serotonergic dysfunction has been implicated in mood disorders and suicidal behaviors. This study examined the association between a serotonin-2A (5HT(2A)) receptor gene polymorphism (102T/C) and mood disorders. The genotype and allele frequencies did not differ between patients with mood disorders and control subjects. Furthermore, the 102T/C polymorphism was not found to be associated with suicidal history in mood disorder patients. Our results suggest that this polymorphism is unlikely to play a role in the genetic susceptibility to mood disorders. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：233 / 237
页数：5
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