Rapid access to conformationally-constrained oxatricycles via Ugi-Smiles couplings

被引：9
作者：
Richey, Bree [1 ]
Mason, Katelynn M. [1 ]
Meyers, Michael S. [1 ]
Luesse, Sarah B. [1 ]
机构：
[1] So Illinois Univ, Dept Chem, Edwardsville, IL 62026 USA
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 04期
关键词：
Ugi-Smiles coupling; Diets-Alder cycloaddition; Oxatricycle; Epoxyisoindoline; Multicomponent coupling reaction; MULTICOMPONENT REACTIONS; ALDER CYCLOADDITION; PRODUCT; AMINES; REARRANGEMENT; HETEROCYCLES; FURANS; IMDAF;
D O I：
10.1016/j.tetlet.2015.12.068
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Use of allylamine and substituted 2-furaldehydes as components in Ugi-Smiles couplings of 2-nitrophenol provide ready access to N-aryl epoxyisoindolines. These adducts form via a dual event involving the Ugi-Smiles multicomponent reaction and an intramolecular Diets-Alder cycloaddition with the furan ring. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：492 / 494
页数：3
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