Prognostic value of inhibitor of apoptosis protein family expression in patients with acute myeloid leukemia

被引：14

作者：

Pluta, Agnieszka ^{[1
]}

Wierzbowska, Agnieszka ^{[1
]}

Cebula-Obrzut, Barbara ^{[2
]}

Pluta, Piotr ^{[3
]}

Stepka, Konrad ^{[1
]}

Szmigielska-Kaplon, Anna ^{[1
]}

Grzybowska-Izydorczyk, Olga ^{[2
]}

Czemerska, Magdalena ^{[1
]}

Smolewski, Piotr ^{[2
]}

Wrzesien-Kus, Agata ^{[1
]}

Robak, Tadeusz ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Hematol, Ciolkowskiego 2, PL-93510 Lodz, Poland

[2] Med Univ Lodz, Dept Expt Hematol, PL-93510 Lodz, Poland

[3] Med Univ Lodz, Dept Surg Oncol, PL-93510 Lodz, Poland

来源：

LEUKEMIA & LYMPHOMA | 2015年 / 56卷 / 09期

关键词：

Acute myeloid leukemia; apoptosis; IAP; prognosis; X-LINKED INHIBITOR; CELL-DEATH; SURVIVIN; XIAP; MECHANISMS; AML;

D O I：

10.3109/10428194.2014.1003052

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The inhibitor of apoptosis protein (IAP) family acts as an inhibitor of apoptosis pathways. The potential prognostic value of the expression of selected IAP family members, XIAP, cIAP-1, cIAP-2 and survivin protein, was evaluated with regard to treatment response and survival of 56 newly diagnosed adult patients with acute myeloid leukemia (AML). The presence of these IAP members influenced the achievement of a complete response (CR). In addition, overall survival (OS) was influenced by low survivin expression in univariate and multivariate analysis (p = 0.014 and p = 0.013, respectively). A strong correlation was observed between members of the IAP family (XIAP and cIAP-1, XIAP and cIAP-2, cIAP-1 and cIAP-2, p < 0.001 for all comparisons), while Smac/DIABLO demonstrated an inverse correlation with XIAP, cIAP-1 and cIAP-2 (p < 0.001 for all comparisons). Further studies should be undertaken to better demonstrate the mode of action of IAP members, as well as their prognostic and therapeutic potentials.

引用

页码：2529 / 2535

页数：7

共 19 条

[1] Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis [J].

Carter, BZ ;

Kornblau, SM ;

Tsao, T ;

Wang, RY ;

Schober, WD ;

Milella, M ;

Sung, HG ;

Reed, JC ;

Andreeff, M .

BLOOD, 2003, 102 (12) :4179-4186

[2] Cytokine-regulated expression of survivin in myeloid leukemia [J].

Carter, BZ ;

Milella, M ;

Altieri, DC ;

Andreeff, M .

BLOOD, 2001, 97 (09) :2784-2790

[3] Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities [J].

Fulda, S. .

LEUKEMIA, 2014, 28 (07) :1414-1422

[4] Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia [J].

Grzybowska-Izydorczyk, Olga ;

Cebula, Barbara ;

Robak, Tadeusz ;

Smolewski, Piotr .

EUROPEAN JOURNAL OF CANCER, 2010, 46 (04) :800-810

[5] An anti-apoptotic pattern correlates with multidrug resistance in acute myeloid leukemia patients: a comparative study of active caspase-3, cleaved PARPs, Bcl-2, Survivin and MDR1 gene [J].

Guenova, Margarita L. ;

Balatzenko, Gueorgui N. ;

Nikolova, Vessela R. ;

Spassov, Branimir V. ;

Konstantinov, Spiro M. .

HEMATOLOGY, 2010, 15 (03) :135-143

[6]

Haferlach Torsten, 2008, Hematology Am Soc Hematol Educ Program, P400, DOI 10.1182/asheducation-2008.1.400

[7] Cladribine, But Not Fludarabine, Added to Daunorubicin and Cytarabine During Induction Prolongs Survival of Patients With Acute Myeloid Leukemia: A Multicenter, Randomized Phase III Study [J].

Holowiecki, Jerzy ;

Grosicki, Sebastian ;

Giebel, Sebastian ;

Robak, Tadeusz ;

Kyrcz-Krzemien, Slawomira ;

Kuliczkowski, Kazimierz ;

Skotnicki, Aleksander B. ;

Hellmann, Andrzej ;

Sulek, Kazimierz ;

Dmoszynska, Anna ;

Kloczko, Janusz ;

Jedrzejczak, Wieslaw W. ;

Zdziarska, Barbara ;

Warzocha, Krzysztof ;

Zawilska, Krystyna ;

Komarnicki, Mieczyslaw ;

Kielbinski, Marek ;

Piatkowska-Jakubas, Beata ;

Wierzbowska, Agnieszka ;

Wach, Malgorzata ;

Haus, Olga .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (20) :2441-2448

[8] Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients [J].

Pluta, Agnieszka ;

Wrzesien-Kus, Agata ;

Cebula-Obrzut, Barbara ;

Wolska, Anna ;

Szmigielska-Kaplon, Anna ;

Czemerska, Magdalena ;

Pluta, Piotr ;

Robak, Tadeusz ;

Smolewski, Piotr ;

Wierzbowska, Agnieszka .

LEUKEMIA RESEARCH, 2010, 34 (10) :1308-1313

[9] Current and Emerging Therapies for Acute Myeloid Leukemia [J].

Robak, Tadeusz ;

Wierbowska, Agnieszka .

CLINICAL THERAPEUTICS, 2009, 31 :2349-2370

[10] Cancer Statistics, 2014 [J].

Siegel, Rebecca ;

Ma, Jiemin ;

Zou, Zhaohui ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2014, 64 (01) :9-29

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