Synthesis of dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepines; derivatives of a novel ring system

被引：10

作者：

Akbarzadeh, Marzieh ^{[1
]}

Bakavoli, Mehdi ^{[1
]}

Eshghi, Hossein ^{[1
]}

Shiri, Ali ^{[1
]}

Tajabadi, Javad ^{[1
]}

机构：

[1] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad 917751436, Iran

来源：

JOURNAL OF CHEMICAL RESEARCH | 2015年 / 09期

关键词：

dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine; heterocyclisation; 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine; FACILE SYNTHESIS; IDENTIFICATION; ANTAGONISTS; DESIGN;

D O I：

10.3184/174751915X14401726334645

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several derivatives of the novel dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine ring system have been synthesised through the initial heterocyclisation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with o-aminothiophenol followed by treatment with various secondary amines in boiling ethanol.

引用

页码：531 / 534

页数：4

共 32 条

[1] Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors [J].

Bakavoli, M. ;

Nikpour, M. ;

Rahimizadeh, M. ;

Saberi, M. R. ;

Sadeghian, H. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (05) :2120-2126

[2] Facile synthesis of 2-anilinopyrimido [4,5-e][1,3,4]thiadiazines [J].

Bakavoli, Mehdi ;

Rahimizadeh, Mohammad ;

Shiri, Ali ;

Eshghi, Hossein ;

Nickpour, Mohsen .

HETEROCYCLES, 2008, 75 (07) :1745-1748

[3] Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils [J].

Bakavoli, Mehdi ;

Eshghi, Hossein ;

Shiri, Ali ;

Afrough, Toktam ;

Tajabadi, Javad .

TETRAHEDRON, 2013, 69 (39) :8470-8476

[4] Synthesis and Antibacterial Evaluations of New Pyridazino-[4,3-e][1,3,4]oxadiazines [J].

Bakavoli, Mehdi ;

Rahimizadeh, Mohammad ;

Shiri, Ali ;

Eshghi, Hossein ;

Pordeli, Parvaneh ;

Pordel, Mehdi ;

Nikpour, Mohsen .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 48 (01) :149-152

[5] Synthesis of New Derivatives of 3-Aryl-1,5-dimethyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e][1,3,4]oxadiazines as Potential Antiproliferative Agents [J].

Bakavoli, Mehdi ;

Rahimizadeh, Mohammad ;

Shiri, Ali ;

Akbarzadeh, Marzieh ;

Mousavi, Seyed-Hadi ;

Tayarani-Najaran, Zahra ;

Atapour-Mashhad, Hoda ;

Nikpour, Mohsen .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 48 (01) :183-187

[6] Synthesis and anticancer evaluation of new derivatives of 3-phenyl-1,5-dimethyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e][1,3,4]oxadiazine [J].

Bakavoli, Mehdi ;

Rahimizadeh, Mohammad ;

Shiri, Ali ;

Akbarzadeh, Marzieh ;

Mousavi, Seyed-Hadi ;

Atapour-Mashhad, Hoda ;

Tayarani-Najaran, Zahra .

JOURNAL OF CHEMICAL RESEARCH, 2010, (07) :403-406

[7] Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents [J].

Bakavoli, Mehdi ;

Bagherzadeh, Ghodsieh ;

Vaseghifar, Maryam ;

Shiri, Ali ;

Pordel, Mehdi ;

Mashreghi, Mansour ;

Pordeli, Parvaneh ;

Araghi, Maryam .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (02) :647-650

[8] Iodine catalysed synthesis and antibacterial evaluation of thieno[2,3-d] pyrimidine derivatives [J].

Bakavoli, Mehdi ;

Bagherzadeh, Ghodsieh ;

Vaseghifar, Maryam ;

Shiri, Ali ;

Pordeli, Parvaneh .

JOURNAL OF CHEMICAL RESEARCH-S, 2009, (11) :653-655

[9] 1,5-Benzothiazepine, a versatile pharmacophore: A review [J].

Bariwal, Jitender B. ;

Upadhyay, Kuldip D. ;

Manvar, Atul T. ;

Trivedi, Jalpa C. ;

Singh, Jyoti S. ;

Jain, Kishor S. ;

Shah, Anarmik K. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (11) :2279-2290

[10] Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents [J].

Campiani, G ;

Butini, S ;

Fattorusso, C ;

Catalanotti, B ;

Gemma, S ;

Nacci, V ;

Morelli, E ;

Cagnotto, A ;

Mereghetti, I ;

Mennini, T ;

Carli, M ;

Minetti, P ;

Di Cesare, MA ;

Mastroianni, D ;

Scafetta, N ;

Galletti, B ;

Stasi, MA ;

Castorina, M ;

Pacifici, L ;

Vertechy, M ;

Di Serio, S ;

Ghirardi, O ;

Tinti, O ;

Carminati, P .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (01) :143-157

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