Synthesis, structure and anti-acetylcholinesterase activity of 4 beta-methoxymethyl-4 beta-demethyl territrem B

被引：3
作者：
Peng, FC [1 ]
Cheng, JS [1 ]
机构：
[1] NATL TAIWAN UNIV,COLL MED,INST PHARMACOL,TAIPEI,TAIWAN
来源：
MYCOPATHOLOGIA | 1997年 / 137卷 / 02期
关键词：
acetylcholinesterase; Aspergillus terreus 23-1; dimethyl sulfate; 4 beta-hydroxymethyl-4 beta-demethyl territrem B; 4 beta-methoxymethyl-4 beta-demethylterritrem B; territrem A; territrem B; territrem C; tremorgenic mycotoxin;
D O I：
10.1023/A:1006845621623
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
4 beta-Methoxymethyl-4 beta-demethyl territrem B [5] was synthesized from 4 beta-hydroxymethyl-beta-demethyl territrem B [4] by treatment with dimethyl sulfate in methanolic NaOH. The structure of 5 was elucidated by uv, nmr and mass spectra. The IC50 of 5 on acetylcholinesterase (AChE) was 6.30 x 10(-5) M, which indicated 0.4% of the anti-AChE activity of territrem B [2].
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页码：125 / 128
页数：4
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