Highly diastereoselective and enantioselective C-H functionalization of 1,2-dihydronaphthalenes: A combined C-H activation/cope rearrangement followed by a retro-cope rearrangement

被引：66

作者：

Davies, HML ^{[1
]}

Jin, QH ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 35期

关键词：

D O I：

10.1021/ja047185k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Rh2(S-DOSP)4-catalyzed reaction of vinyldiazoacetates with dihydronaphthalenes results in a highly enantioselective (91-99.6% ee) and diastereoselective (>98% de) C-H functionalization. The apparent intermolecular C-H insertion was demonstrated to be a combined C-H activation/Cope rearrangement followed by a retro-Cope rearrangement. Copyright © 2003 American Chemical Society.

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页码：10862 / 10863

页数：2

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