Overexpression of VCC-1 gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion

被引：27

作者：

Mu, Xia ^{[1
,2
]}

Chen, Yao ^{[1
]}

Wang, Shuihai ^{[1
]}

Huang, Xiang ^{[1
]}

Pan, Huazhen ^{[1
]}

Li, Ming ^{[1
]}

机构：

[1] So Med Univ, Sch Biotechnol, Guangzhou 510515, Guangdong, Peoples R China

[2] Guizhou Prov Ctr Dis Prevent & Control, Inst Infect Dis, Guiyang 550004, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2009年 / 41卷 / 08期

基金：

国家高技术研究发展计划(863计划);

关键词：

chemokine; hepatocellular carcinoma; VCC-1; tumorigenesis; CHEMOKINE; ANGIOGENESIS; GROWTH; LINE;

D O I：

10.1093/abbs/gmp051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial growth factor-correlated chemokine 1 (VCC-1), a novel chemokine, is hypothesized to be associated with carcinogenesis. VCC-1 is expressed in hepatocellular carcinoma (HCC) cells, but its function remains unknown. To investigate the molecular effects of VCC-1 on HCC cells, the HCC cell line SMMC7721 was stably transfected with the recombinant plasmid pcDNA3.1/VCC-1. Our data demonstrated that overexpression of VCC-1 in SMMC7721 cells significantly enhanced the cellular proliferation, invasive ability, and tumor growth, when compared with both empty vector control cells and parental cells. These results strongly suggest that VCC-1 plays an important role in SMMC7721 invasion and tumor growth, and indicate that VCC-1 may serve as a potential biomarker for anti-HCC therapies.

引用

页码：631 / 637

页数：7

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