Epidemiology of Mucinous Adenocarcinomas

Simple Summary Mucinous adenocarcinomas are a very uncommon type of cancer that is poorly studied. These cancers overexpress a jelly-like substance called mucin outside their cells. These cancers share characteristics to another group of cancers called signet ring cell adenocarcinomas, which express mucin inside their cells, and these cancers almost invariability have a worse outcome compared to conventional adenocarcinomas. In our study, we show that patient outcomes with mucinous adenocarcinomas depend largely on the site of the cancer, with both similarities and differences to cancers arising from signet ring cells. This work, along with our recent study on signet ring cell cancers, provides a solid epidemiological reference for future work to motivate investigations as to how recognizing this tumor histology should lead to more tailored cancer treatments in order to improve patient outcomes. Mucinous (colloid) adenocarcinomas (MAs) are a rare histological subtype of adenocarcinomas where extracellular mucin comprises more than 50% of the tumor. Most literature on MAs relate to cancers from colorectal and breast sites; however, the literature lacks a standardized overview of the MA disease entity. Particularly in colorectal cancer, some MAs may have signet ring cells floating within the mucin, which may represent a highly metastatic phenotype. MAs and signet ring cell adenocarcinomas represent a spectrum of mucin-producing neoplastic conditions where in the latter most mucin is intracellular rather than extracellular. We recently published a standardized overview of signet ring cells, and in this companion work, using a retrospective cohort approach, we summarize the clinicodemographic and mortality outcomes of MAs in sixteen primary sites, comprising 95.6% of all MAs in the Surveillance, Epidemiology, and End Results Program (SEER), a population-level cancer database covering nearly one-third of the United States population. Compared to matching nonvariant adenocarcinomas, MAs have a slightly earlier age of onset with increased rates of regional and distant disease at presentation. Survival outcomes are highly dependent on tumor location, illustrating our poor understanding of MA tumor biology. The clinical significance of MA histology depends largely on tumor site.