Maximum Voided Volume Is a Better Clinical Parameter for Bladder Capacity Than Maximum Cystometric Capacity in Patients With Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Prospective Cohort Study

Purpose: Bladder capacity is an important parameter in the diagnosis of lower urinary tract dysfunction. We aimed to deter-mine whether the maximum bladder capacity (MCC) measured during a urodynamic study was affected by involuntary de-trusor contraction (IDC) in patients with Lower Urinary Tract Symptoms (LUTS)/Benign Prostatic Hyperplasia (BPH).Methods: Between March 2020 and April 2021, we obtained maximum voided volume (MVV) from a 3-day frequency -vol-ume chart, MCC during filling cystometry, and maximum anesthetic bladder capacity (MABC) during holmium laser enucle-ation of the prostate under spinal or general anesthesia in 139 men with LUTS/BPH aged >50 years. Patients were divided ac-cording to the presence of IDC during filling cystometry. We assumed that the MABC is close to the true value of the MCC, as it is measured under the condition of minimizing neural influence over the bladder.Results: There was no difference in demographic and clinical characteristics between the non-IDC (n= 20) and IDC groups (n =119) (mean age, 71.5 +/- 7.4) (P > 0.05). The non-IDC group had greater bladder volume to feel the first sensation, first de-sire, and strong desire than the IDC group (P < 0.001). In all patients, MABC and MVV were correlated (r= 0.41, P < 0.001); however, there was no correlation between MCC and MABC (r = 0.19, P = 0.02). There was no significant difference in MABC between the non-IDC and IDC groups (P = 0.19), but MVV and MCC were significantly greater in the non-IDC group (P < 0.001). There was no significant difference between MABC and MVV (MABC-MVV, P =0.54; MVV/MABC, P = 0.07), but there was a significant difference between MABC and MCC between the non-IDC and IDC groups (MABC-MCC, P < 0.001; MCC/MABC, P < 0.001).Conclusions: Maximum bladder capacity from a urodynamic study does not represent true bladder capacity because of invol-untary contractions.