Cytology is useful in breast screening: results and long-term follow-up of the Singapore Breast Screening Pilot Project

Objective: The Singapore Breast Screening Pilot Project (SBSPP) was embarked upon ( 1994 - 1997) to determine if mammography was useful in early breast cancer detection among Asian women. Patients and measurements: Of 28 231 women screened, fine needle aspiration cytology (FNAC) was performed in 232 individuals as part of the triple assessment. Results: Absolute and complete sensitivities for the diagnosis of carcinoma were 46.7% and 82.2%, respectively, based on the results of FNAC. Specificity was 63.3%. The inadequate rate was 31%. Five women who were considered cancer-free on triple assessment and, in two cases open diagnostic biopsy during the SBSPP, subsequently developed breast cancer after a median follow-up of 6 years. Conclusion: Although our FNAC results compared relatively well with international standards, they reflect a small cohort, and may face additional difficulties in a larger programme.