Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides

被引：204

作者：

Han, Chong ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 22期

关键词：

CROSS-COUPLINGS; ORGANOZINC REAGENTS; ORGANIC HALIDES; CATALYST; DISCOVERY; GRIGNARD;

D O I：

10.1021/ja902046m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient palladium-catalyzed process has been developed for Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. A palladium catalyst composed of a new biaryidialkylphosphine ligand, CPhos, effectively promotes the rate of the reductive elimination step relative to the rate of the undesired B-hydride elimination. The broad substrate scope and excellent ratio of the desired secondary to the undesired primary coupling product make this method a powerful and reliable tool for C(sp(3))-C(sp(2)) bond formation.

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页码：7532 / +

页数：3

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