Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C-H monoarylation

被引：5

作者：

Abidi, Oumaima ^{[1
,2
]}

Boubaker, Taoufik ^{[2
]}

Hierso, Jean-Cyrille ^{[1
,3
]}

Roger, Julien ^{[1
]}

机构：

[1] UBFC, Univ Bourgogne, CNRS, UMR 6302,Inst Chim Mol, 9 Ave Alain Savary, F-21078 Dijon, France

[2] Univ Monastir, Lab Chim Heterocycl Prod Nat & React, Ave Environm, Monastir 5019, Tunisia

[3] IUF, 103 Blvd St Michel, F-75005 Paris, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 24期

关键词：

DIRECT ARYLATIONS; CARBOXYLIC-ACIDS; ARYL; FUNCTIONALIZATIONS; FLUORINATION; WATER;

D O I：

10.1039/c9ob00806c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Metal-catalysed ortho-directed C-H functionalization usually faces selectivity issues in the competition between mono- and disubstitution processes. We report herein the ruthenium-catalysed N-directed C-H monoarylation of arylpyrazoles with a selectivity of up to 96% or that generally reaches values above 80%. This selectivity is an effect of solvent-free conditions associated with sulfonate reagents, in the absence of frequently used acidic additives.

引用

页码：5916 / 5919

页数：4

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