The guanidine metabolites of Ptilocaulis spiculifer and related compounds; isolation and synthesis

被引：247
作者：
Heys, L [1 ]
Moore, CG [1 ]
Murphy, PJ [1 ]
机构：
[1] Univ Wales, Dept Chem, Bangor LL57 2UW, Gwynedd, Wales
来源：
CHEMICAL SOCIETY REVIEWS | 2000年 / 29卷 / 01期
关键词：
D O I：
10.1039/a903712h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Marine natural products possessing guanidine functionalities display a considerable array of biological activity and not surprisingly have attracted considerable synthetic interest. This review discusses the isolation of several guanidine containing metabolites, primarily from the sponge Ptilocaulis spiculifer , but also from other marine organisms. It also explores the synthetic methodologies adopted for their preparation and speculates on the structural similarity of the metabolite ptilomycalin A to abiotic guanidine based anionic receptor molecules.
引用
收藏
页码：57 / 67
页数：11
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