A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO

被引：200
作者：
Fan, Jing [1 ,2 ,3 ]
He, Nongyue [1 ]
He, Qianjun [4 ]
Liu, Yi [3 ]
Ma, Ying [3 ]
Fu, Xiao [3 ]
Liu, Yijing [3 ]
Huang, Peng [3 ]
Chen, Xiaoyuan [3 ]
机构：
[1] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China
[2] Nanxishan Hosp Guangxi Zhuang Nationality Autonom, Clin Lab, Guilin 541002, Guangxi, Peoples R China
[3] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
[4] Shenzhen Univ, Sch Med, Dept Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasoun, Shenzhen 518060, Guangdong, Peoples R China
来源：
NANOSCALE | 2015年 / 7卷 / 47期
基金：
美国国家卫生研究院;
关键词：
NITRIC-OXIDE; GRAPHENE OXIDE; DELIVERY; EFFICIENT; MULTIPLICATION; NANOPARTICLES; DOXORUBICIN; GENERATION; EXCITATION;
D O I：
10.1039/c5nr06630a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembly of graphene oxide (GO) nanosheets and a NO donor BNN6 through the pi-pi stacking interaction. The GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, irradiation time and power density of NIR laser. The intracellular NIR-responsive release of NO from the GO-BNN6 nanomedicine causes a remarkable anti-cancer effect.
引用
收藏
页码：20055 / 20062
页数：8
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