A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO

被引：203

作者：

Fan, Jing ^{[1
,2
,3
]}

He, Nongyue ^{[1
]}

He, Qianjun ^{[4
]}

Liu, Yi ^{[3
]}

Ma, Ying ^{[3
]}

Fu, Xiao ^{[3
]}

Liu, Yijing ^{[3
]}

Huang, Peng ^{[3
]}

Chen, Xiaoyuan ^{[3
]}

机构：

[1] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China

[2] Nanxishan Hosp Guangxi Zhuang Nationality Autonom, Clin Lab, Guilin 541002, Guangxi, Peoples R China

[3] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA

[4] Shenzhen Univ, Sch Med, Dept Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasoun, Shenzhen 518060, Guangdong, Peoples R China

来源：

NANOSCALE | 2015年 / 7卷 / 47期

基金：

美国国家卫生研究院;

关键词：

NITRIC-OXIDE; GRAPHENE OXIDE; DELIVERY; EFFICIENT; MULTIPLICATION; NANOPARTICLES; DOXORUBICIN; GENERATION; EXCITATION;

D O I：

10.1039/c5nr06630a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembly of graphene oxide (GO) nanosheets and a NO donor BNN6 through the pi-pi stacking interaction. The GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, irradiation time and power density of NIR laser. The intracellular NIR-responsive release of NO from the GO-BNN6 nanomedicine causes a remarkable anti-cancer effect.

引用

页码：20055 / 20062

页数：8

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