A Novel Regulator of Type II Diabetes: MicroRNA-143

被引：47

作者：

Li, Biao ^{[1
]}

Fan, Jingjing ^{[2
]}

Chen, Ning ^{[2
]}

机构：

[1] Wuhan Sports Univ, Grad Sch, Wuhan 430079, Hubei, Peoples R China

[2] Wuhan Sports Univ, Coll Hlth Sci, Tianjiu Res & Dev Ctr Exercise Nutr & Foods, Hubei Key Lab Sport Training & Monitoring, Wuhan 430079, Hubei, Peoples R China

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 06期

基金：

中国国家自然科学基金;

关键词：

TRANSCRIPTION FACTOR FOXO1; CELL-PROLIFERATION; SIGNALING PATHWAY; MUSCLE ATROPHY; UP-REGULATION; AUTOPHAGY; INSULIN; EXPRESSION; GLUCOSE; OBESITY;

D O I：

10.1016/j.tem.2018.03.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM). Aerobic exercise can prevent T2DM by downregulating miR-143. However, the underlying mechanisms for exercise-induced change of miR-143 remain unclear. In the present study, we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143.

引用

页码：380 / 388

页数：9

共 70 条

[41] Structural basis of target recognition by Atg8/LC3 during selective autophagy [J].

Noda, Nobuo N. ;

Kumeta, Hiroyuki ;

Nakatogawa, Hitoshi ;

Satoo, Kenji ;

Adachi, Wakana ;

Ishii, Junko ;

Fujioka, Yuko ;

Ohsumi, Yoshinori ;

Inagaki, Fuyuhiko .

GENES TO CELLS, 2008, 13 (12) :1211-1218

[42] Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis [J].

O'Neill, Brian T. ;

Lee, Kevin Y. ;

Klaus, Katherine ;

Softic, Samir ;

Krumpoch, Megan T. ;

Fentz, Joachim ;

Stanford, Kristin I. ;

Robinson, Matthew M. ;

Cai, Weikang ;

Kleinridders, Andre ;

Pereira, Renata O. ;

Hirshman, Michael F. ;

Abel, E. Dale ;

Accili, Domenico ;

Goodyear, Laurie J. ;

Nair, K. Sreekumaran ;

Kahn, C. Ronald .

JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (09) :3433-3446

[43] MicroRNA links obesity and impaired glucose metabolism [J].

Ono, Koh .

CELL RESEARCH, 2011, 21 (06) :864-866

[44]

Piek E, 1999, J CELL SCI, V112, P4557

[45] Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction [J].

Puigserver, P ;

Rhee, J ;

Donovan, J ;

Walkey, CJ ;

Yoon, JC ;

Oriente, F ;

Kitamura, Y ;

Altomonte, J ;

Dong, HJ ;

Accili, D ;

Spiegelman, BM .

NATURE, 2003, 423 (6939) :550-555

[46] The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children [J].

Rask-Andersen, Mathias ;

Jacobsson, Josefin A. ;

Moschonis, George ;

Ek, Anna E. ;

Chrousos, George P. ;

Marcus, Claude ;

Manios, Yannis ;

Fredriksson, Robert ;

Schioth, Helgi B. .

BMC MEDICAL GENETICS, 2012, 13

[47] Acute exercise modulates the Foxo1/PGC-1α pathway in the liver of diet-induced obesity rats (Publication with Expression of Concern. See vol. 594, pg. 5029, 2016) [J].

Ropelle, Eduardo R. ;

Pauli, Jose R. ;

Cintra, Dennys E. ;

Frederico, Marisa J. S. ;

de Pinho, Ricardo A. ;

Velloso, Licio A. ;

De Souza, Claudio T. .

JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (09) :2069-2076

[48] BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans [J].

Sajan, Mini P. ;

Ivey, Robert A., III ;

Farese, Robert V. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2015, 64 (11) :1454-1465

[49] Circulating microRNAs and diabetes mellitus: a novel tool for disease prediction, diagnosis, and staging? [J].

Sebastiani, G. ;

Nigi, L. ;

Grieco, G. E. ;

Mancarella, F. ;

Ventriglia, G. ;

Dotta, F. .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2017, 40 (06) :591-610

[50] Autophagy in health and disease: A double-edged sword [J].

Shintani, T ;

Klionsky, DJ .

SCIENCE, 2004, 306 (5698) :990-995

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