A Novel Regulator of Type II Diabetes: MicroRNA-143

被引：47

作者：

Li, Biao ^{[1
]}

Fan, Jingjing ^{[2
]}

Chen, Ning ^{[2
]}

机构：

[1] Wuhan Sports Univ, Grad Sch, Wuhan 430079, Hubei, Peoples R China

[2] Wuhan Sports Univ, Coll Hlth Sci, Tianjiu Res & Dev Ctr Exercise Nutr & Foods, Hubei Key Lab Sport Training & Monitoring, Wuhan 430079, Hubei, Peoples R China

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 06期

基金：

中国国家自然科学基金;

关键词：

TRANSCRIPTION FACTOR FOXO1; CELL-PROLIFERATION; SIGNALING PATHWAY; MUSCLE ATROPHY; UP-REGULATION; AUTOPHAGY; INSULIN; EXPRESSION; GLUCOSE; OBESITY;

D O I：

10.1016/j.tem.2018.03.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM). Aerobic exercise can prevent T2DM by downregulating miR-143. However, the underlying mechanisms for exercise-induced change of miR-143 remain unclear. In the present study, we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143.

引用

页码：380 / 388

页数：9

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