Discovery and functional characterization of cardiovascular long noncoding RNAs

被引：42
作者：
Ounzain, Samir [1 ]
Burdet, Frederic [2 ]
Ibberson, Mark [2 ]
Pedrazzini, Thierry [1 ]
机构：
[1] Univ Lausanne, Sch Med, Dept Med, Expt Cardiol Unit, Lausanne, Switzerland
[2] Univ Lausanne, Swiss Inst Bioinformat, Vital IT, Lausanne, Switzerland
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2015年 / 89卷
基金：
瑞士国家科学基金会;
关键词：
Cardiovascular disease; Long noncoding RNA; Genomics; Discovery; Functional characterization; HEART; MECHANISMS; REVEALS; IDENTIFICATION; TRANSCRIPTION; INTERACTOME; DIAGNOSIS;
D O I：
10.1016/j.yjmcc.2015.09.013
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent advances in sequencing and genomic technologies have resulted in the discovery of thousands of previously unannotated long noncoding RNAs (lncRNAs). However, their function in the cardiovascular system remains elusive. Here we review and discuss considerations for cardiovascular lncRNA discovery, annotation and functional characterization. Although we primarily focus on the heart, the proposed pipeline should foster functional and mechanistic exploration of these transcripts in various cardiovascular pathologies. Moreover, these insights could ultimately lead to novel therapeutic approaches targeting lncRNAs for the amelioration of cardiovascular diseases including heart failure. (c) 2015 The Authors. Published by Elsevier Ltd.
引用
收藏
页码：17 / 26
页数：10
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