Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 expression: is it right now a safe and promising therapeutic approach for atherosclerosis?

被引：0
作者：
Fratta Pasini, Anna [1 ]
Garbin, Ulisse [1 ]
Cominacini, Luciano [1 ]
机构：
[1] Univ Verona, Dept Biomed & Surg Sci, Sect Internal Med, I-37134 Verona, Italy
来源：
JOURNAL OF HYPERTENSION | 2009年 / 27卷 / 03期
关键词：
DOUBLE-EDGED-SWORD; OX-LDL RECEPTOR-1; ENDOTHELIAL-CELLS; KAPPA-B; LOX-1; GENE; ACTIVATION; BINDING; INJURY; DISEASE;
D O I：
10.1097/HJH.0b013e328326069a
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
引用
收藏
页码：452 / 455
页数：4
相关论文
共 33 条
[1]   Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene [J].
Aoyama, T ;
Sawamura, T ;
Furutani, Y ;
Matsuoka, R ;
Yoshida, MC ;
Fujiwara, H ;
Masaki, T .
BIOCHEMICAL JOURNAL, 1999, 339 :177-184
[2]   Angiotensin peptides and inducible transcription factors [J].
Blume, A ;
Herdegen, T ;
Unger, T .
JOURNAL OF MOLECULAR MEDICINE-JMM, 1999, 77 (03) :339-357
[3]   LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis [J].
Chen, MJ ;
Masaki, T ;
Sawamura, T .
PHARMACOLOGY & THERAPEUTICS, 2002, 95 (01) :89-100
[4]   Increased expression of lectinlike oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits [J].
Chen, MY ;
Kakutani, M ;
Minami, M ;
Kataoka, H ;
Kume, N ;
Narumiya, S ;
Kita, T ;
Masaki, T ;
Sawamura, T .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (04) :1107-1115
[5]   Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis? [J].
Chen, Xiu-Ping ;
Zhang, Tian-Tai ;
Du, Guan-Hua .
CARDIOVASCULAR DRUG REVIEWS, 2007, 25 (02) :146-161
[6]   Enhanced plasma levels of oxidized low-density lipoprotein increase circulating nuclear factor-kappa B activation in patients with unstable angina [J].
Cominacini, L ;
Anselmi, M ;
Garbin, U ;
Fratta Pasini, A ;
Stranieri, C ;
Fusaro, M ;
Nava, C ;
Agostoni, P ;
Keta, D ;
Zardini, P ;
Sawamura, T ;
Lo Cascio, V .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 46 (05) :799-806
[7]   The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide [J].
Cominacini, L ;
Rigoni, A ;
Fratta Pasini, A ;
Garbin, U ;
Davoli, A ;
Campagnola, R ;
Pastorino, AM ;
Lo Cascio, V ;
Sawamura, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (17) :13750-13755
[8]   Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of intracellular reactive oxygen species [J].
Cominacini, L ;
Fratta Pasini, A ;
Garbin, U ;
Davoli, A ;
Tosetti, ML ;
Campagnola, M ;
Rigoni, A ;
Pastorino, AM ;
Lo Cascio, V ;
Sawamura, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (17) :12633-12638
[9]   The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease [J].
Dunn, Sarah ;
Vohra, Ravinder S. ;
Murphy, Jane E. ;
Homer-Vanniasinkam, Shervanthi ;
Walker, John H. ;
Ponnambalam, Sreenivasan .
BIOCHEMICAL JOURNAL, 2008, 409 :349-355
[10]   AP-1: A double-edged sword in tumorigenesis [J].
Eferl, R ;
Wagner, EF .
NATURE REVIEWS CANCER, 2003, 3 (11) :859-868
1234