Therapeutic Drug Monitoring of antiinfectives in intensive care medicine

被引：8
作者：
Nosseir, N. S. [1 ]
Michels, G. [2 ]
Pfister, R. [2 ]
Adam, R. [3 ]
Wiesen, M. H. J. [1 ]
Mueller, C. [1 ]
机构：
[1] Inst Pharmakol, TDM Labor, Cologne, Germany
[2] Uniklin Koln, Herzzentrum Klin Innere Med 3, Cologne, Germany
[3] Uniklin Bonn, Inst Humangenet, Bonn, Germany
来源：
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2014年 / 139卷 / 38期
关键词：
therapeutic drug monitoring; intensive care medicine; pharmacokinetics; pharmacodynamics; aminoglycosides; vancomycin; CONTINUOUS VENOVENOUS HEMOFILTRATION; RENAL REPLACEMENT THERAPY; CRITICALLY-ILL PATIENTS; CONTINUOUS-INFUSION; PSEUDOMONAS-AERUGINOSA; UNIT PATIENTS; VANCOMYCIN; PHARMACOKINETICS; NEPHROTOXICITY; NEUROTOXICITY;
D O I：
10.1055/s-0034-1387215
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Therapeutic Drug Monitoring (TDM) is based on drug-level control in biological matrices and serves as a diagnostic approach for individualization of pharmacotherapy and drug safety. Drug levels of antibiotics are distinctly influenced by comorbidity, physiological changes and various concomitant drugs in patients on intensive care units. Several factors should be taken into account for calculation of relevant pharmacokinetic parameters (elimination half-life, bioavailability, and clearance) to deduce a recommendation for dosage. TDM is a diagnostic standard for the individualization of polypharmcotherapy based on validated analytical methods (in particular LC-MS/MS and HPLC-methods) in order to optimize dosing and drug safety.
引用
收藏
页码：1889 / 1894
页数：6
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