Genetic Variations in ABCG2 Gene Predict Breast Carcinoma Susceptibility and Clinical Outcomes after Treatment with Anthracycline-Based Chemotherapy

被引：16
作者：
Wu, Huizhe [1 ]
Liu, Yong [2 ]
Kang, Hui [3 ]
Xiao, Qinghuan [1 ]
Yao, Weifan [1 ]
Zhao, Haishan [1 ]
Wang, Enhua [4 ,5 ]
Wei, Minjie [1 ]
机构：
[1] China Med Univ, Sch Pharm, Dept Pharmacol, Shenyang 110122, Liaoning, Peoples R China
[2] China Med Univ, Dept Clin Lab, Shengjing Hosp, Heping Ward, Shenyang 110003, Liaoning, Peoples R China
[3] China Med Univ, Dept Clin Lab, Hosp 1, Heping Ward, Shenyang 110003, Liaoning, Peoples R China
[4] China Med Univ, Inst Pathol & Pathophysiol, Hosp 1, Heping Ward, Shenyang 110003, Liaoning, Peoples R China
[5] China Med Univ, Coll Basic Med Sci, Heping Ward, Shenyang 110003, Liaoning, Peoples R China
来源：
BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷
基金：
中国国家自然科学基金;
关键词：
CANCER RESISTANCE PROTEIN; SINGLE NUCLEOTIDE POLYMORPHISMS; MULTIDRUG-RESISTANCE; FUNCTIONAL ASSESSMENT; C421A POLYMORPHISM; BCRP; ABCB1; EXPRESSION; TRANSPORTER; VARIANTS;
D O I：
10.1155/2015/279109
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The genetic variants of the ATP-binding cassette, subfamily G, member 2 (ABCG2) are known to be involved in developing cancer risk and interindividual differences in chemotherapeutic response. The polymorphisms in ABCG2 gene were genotyped by using PCR-RFLP assays. We found that ABCG2 G34A GA/AA genotype, C421A AA genotype, and haplotypes 34A-421C and 34G-421A were significantly associated with increased risk for developing breast carcinoma. Furthermore, ABCG2 C421A AA homozygote had a significant enhanced therapeutic response in patients with neoadjuvant anthracycline-based chemotherapy. Moreover, ABCG2 G34A AA genotype carriers displayed a longer OS in ER positive patients or PR positive patients after postoperative anthracycline-based chemotherapy. These results suggested that the ABCG2 polymorphisms might be a candidate pharmacogenomic factor to assess susceptibility and prognosis for breast carcinoma patients.
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页数：12
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