Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion

被引：10

作者：

Ning, Liping ^{[1
]}

Wang, Chuanwei ^{[2
]}

Fan, Xiaohua ^{[1
]}

Ding, Xinli ^{[1
]}

Wang, Yonghui ^{[3
]}

Zhang, Yang ^{[3
]}

Wang, Jie ^{[3
]}

Yue, Shouwei ^{[3
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Dept Rehabil, Jinan 250012, Peoples R China

[2] Shandong Univ, Qilu Hosp, Dept Neurosurg, Jinan 250012, Peoples R China

[3] Shandong Univ, Qilu Hosp, Dept Phys Med & Rehabil, Jinan 250012, Peoples R China

来源：

NEUROLOGICAL RESEARCH | 2014年 / 36卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Microtubule depolymerization; Colchicine; Transient receptor potential vanilloid 4; Hyperalgesia; CCD; MECHANICAL HYPERALGESIA; CYTOSKELETON; CHANNEL; NERVE; MODEL;

D O I：

10.1179/1743132813Y.0000000261

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this study is to investigate the effect of microtubule depolymerization by colchicine on hyperalgesia mediated by transient receptor potential vanilloid 4 (TRPV4) in a neuropathic pain model of chronic compression of the dorsal root ganglion (DRG) (hereafter termed CCD) in rat. Intrathecal administration of microtubule-depolymerizing agent, colchicine, attenuated the activated effect of 4alpha-phorbol 12, 13-didecanoate (4alpha-PDD, TRPV4 specific agonist) on mechanical and thermal hyperalgesia in CCD rats. This observation is in agreement with our in vitro experiments with DRG cells that showed a significant attenuation of 4alpha-PDD-activated Ca 2z -influx and substance P (SP) release with the colchicine treatment. We conclude that microtubule depolymerization by colchicine can regulate pain sensitivity by depressing the hyperalgesia mediated by TRPV4.

引用

页码：70 / 78

页数：9

共 32 条

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Li, Qian
Cheng, Yun
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