Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion

被引：10
作者：
Ning, Liping [1 ]
Wang, Chuanwei [2 ]
Fan, Xiaohua [1 ]
Ding, Xinli [1 ]
Wang, Yonghui [3 ]
Zhang, Yang [3 ]
Wang, Jie [3 ]
Yue, Shouwei [3 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Dept Rehabil, Jinan 250012, Peoples R China
[2] Shandong Univ, Qilu Hosp, Dept Neurosurg, Jinan 250012, Peoples R China
[3] Shandong Univ, Qilu Hosp, Dept Phys Med & Rehabil, Jinan 250012, Peoples R China
来源：
NEUROLOGICAL RESEARCH | 2014年 / 36卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Microtubule depolymerization; Colchicine; Transient receptor potential vanilloid 4; Hyperalgesia; CCD; MECHANICAL HYPERALGESIA; CYTOSKELETON; CHANNEL; NERVE; MODEL;
D O I：
10.1179/1743132813Y.0000000261
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The aim of this study is to investigate the effect of microtubule depolymerization by colchicine on hyperalgesia mediated by transient receptor potential vanilloid 4 (TRPV4) in a neuropathic pain model of chronic compression of the dorsal root ganglion (DRG) (hereafter termed CCD) in rat. Intrathecal administration of microtubule-depolymerizing agent, colchicine, attenuated the activated effect of 4alpha-phorbol 12, 13-didecanoate (4alpha-PDD, TRPV4 specific agonist) on mechanical and thermal hyperalgesia in CCD rats. This observation is in agreement with our in vitro experiments with DRG cells that showed a significant attenuation of 4alpha-PDD-activated Ca 2z -influx and substance P (SP) release with the colchicine treatment. We conclude that microtubule depolymerization by colchicine can regulate pain sensitivity by depressing the hyperalgesia mediated by TRPV4.
引用
收藏
页码：70 / 78
页数：9
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