Hannahpep:: A novel fibrinolytic peptide from the Indian King Cobra (Ophiophagus hannah) venom

被引:16
作者
Gomes, A [1 ]
De, P [1 ]
机构
[1] Univ Calcutta, Dept Physiol, Lab Toxinol & Expt Pharmacodynam, Kolkata 700009, W Bengal, India
关键词
snake venom; Ophiophagus hannah; King Cobra; fibrinolytic factor; thrombolytic factor;
D O I
10.1006/bbrc.1999.1818
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A novel fibrinolytic peptide (Hannahpep) was isolated and purified from the venom of the Indian King Cobra (Ophiophagus hannah) by thin-layer chromatography followed by reverse-phase high-performance liquid chromatography. The MW of the peptide was found to be 610 Ha and the amino acid sequence of Hannahpep was determined to be Arg, His, Ala, Arg, His, Asp. Hannahpep produced defibrinogenating activity in male albino mice. It exhibited significant fibrinolytic and fibrinogenolytic activity in vitro. Hannahpep showed plasma-anticlotting activity. However, it lacked hemolytic, hemorrhagic, or phospholipase activity. This peptide may have possible therapeutic application in the management of thrombosis or occlusion of a blood vessel. (C) 1999 Academic Press.
引用
收藏
页码:488 / 491
页数:4
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