In search of new chemical entities with spermicidal and anti-HIV activities

被引：107

作者：

Srivastava, S

Bajpai, LK

Batra, S

Bhaduri, AP ^{[1
]}

Maikhuri, JP

Gupta, G

Dhar, JD

机构：

[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Endocrinol, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 11期

关键词：

spermicidal; anti-HIV; bromination; 2-isoxazolines; iso-xazoles; 1-amino-1-cycloalkyl-2-substituted phenyl ethanes;

D O I：

10.1016/S0968-0896(99)00188-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several compounds belonging to 2-isoxazolines (4,5a-c), isoxazoles (3,6a-c) and 1-amino-1-cycloalkyl-2-substituted phenyl ethanes (16-18,a-e) have been synthesised and found to possess spermicidal activity. Out of these a couple of compounds (5a and 6a) exhibit anti-HIV activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2607 / 2613

页数：7

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