Draft Genome Sequence of an Aflatoxigenic Aspergillus Species, A. bombycis

被引：16

作者：

Moore, Geromy G. ^{[1
]}

Mack, Brian M. ^{[1
]}

Beltz, Shannon B. ^{[1
]}

Gilbert, Matthew K. ^{[1
]}

机构：

[1] ARS, Southern Reg Res Ctr, USDA, Washington, DC 20250 USA

来源：

GENOME BIOLOGY AND EVOLUTION | 2016年 / 8卷 / 11期

基金：

美国农业部;

关键词：

Aspergillus bombycis; aflatoxins; genome sequence; phylogenomics; mating-type locus; METABOLITE; GENES; IDENTIFICATION; BIOSYNTHESIS; AFLATREM; FLAVUS;

D O I：

10.1093/gbe/evw238

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Aspergillus bombycis was first isolated from silkworm frass in Japan. It has been reportedly misidentified as A. nomius due to their macro-morphological and chemotype similarities. We sequenced the genome of the A. bombycis Type strain and found it to be comparable in size (37Mb), as well as in numbers of predicted genes (12,266), to other sequenced Aspergilli. The aflatoxin gene cluster in this strain is similar in size and the genes are oriented the same as other B-+G-aflatoxin producing species, and this strain contains a complete but nonfunctional gene cluster for the production of cyclopiazonic acid. Our findings also showed that the A. bombycis Type strain contains a single MAT1-2 gene indicating that this species is likely heterothallic (self-infertile). This draft genome will contribute to our understanding of the genes and pathways necessary for aflatoxin synthesis as well as the evolutionary relationships of aflatoxigenic fungi.

引用

页码：3297 / 3300

页数：4

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