The Role of Glucocorticoids in the Management of COVID-19

被引：24

作者：

Alexaki, Vasileia Ismini ^{[1
,2
]}

Henneicke, Holger ^{[3
,4
,5
]}

机构：

[1] Tech Univ Dresden, Fac Med, Inst Clin Chem & Lab Med, Dresden, Germany

[2] Tech Univ Dresden, Univ Clin Carl Gustav Carus, Dresden, Germany

[3] Tech Univ Dresden, Ctr Regenerat Therapies Dresden, Fetscherstr 74, D-01307 Dresden, Germany

[4] Tech Univ Dresden, Univ Clin Carl Gustav Carus, Dept Med 3, Dresden, Germany

[5] Tech Univ Dresden, Univ Clin Carl Gustav Carus, Ctr Hlth Aging, Dresden, Germany

来源：

HORMONE AND METABOLIC RESEARCH | 2021年 / 53卷 / 01期

关键词：

glucocorticoids inflammation COVID-19; RESPIRATORY-DISTRESS-SYNDROME; LEUCINE-ZIPPER GILZ; ADVERSE EVENTS; MORTALITY; GLUCOSE; RISK; DIFFERENTIATION; INHIBITION; MECHANISM; PATTERNS;

D O I：

10.1055/a-1300-2550

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronavirus disease 2019 (COVID-19), caused by an infection with the novel coronavirus SARS-CoV-2, has resulted in a global pandemic and poses an emergency to public health systems worldwide. COVID-19 is highly infectious and is characterized by an acute respiratory illness that varies from mild flu-like symptoms to the life-threatening acute respiratory distress syndrome (ARDS). As such, there is an urgent need for the development of new therapeutic strategies, which combat the high mortality in severely ill COVID-19 patients. Glucocorticoids are a frontline treatment for a diverse range of inflammatory diseases. Due to their immunosuppressive functions, the use of glucocorticoids in the treatment of COVID-19 patients was initially regarded with caution. However, recent studies concluded that the initiation of systemic glucocorticoids in patients suffering from severe and critical COVID-19 is associated with lower mortality. Herein we review the anti-inflammatory effects of glucocorticoids and discuss emerging issues in their clinical use in the context of COVID-19.

引用

页码：9 / 15

页数：7

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