The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker

被引：13

作者：

Tan, Xuewen ^{[1
,3
]}

Jiang, Haifeng ^{[1
,3
]}

Fang, Yilong ^{[1
,3
]}

Han, Dafei ^{[1
,3
]}

Guo, Yawei ^{[1
,3
]}

Wang, Xinming ^{[2
]}

Gong, Xun ^{[1
,3
]}

Hong, Wenming ^{[2
]}

Tu, Jiajie ^{[1
,3
]}

Wei, Wei ^{[1
,3
]}

机构：

[1] Anhui Med Univ, Inst Clin Pharmacol, Anhui Collaborat Innovat Ctr Antiinflammatory & I, Key Lab Antiinflammatory & Immune Med,Minist Educ, Hefei, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China

[3] 81 Meishan Rd, Hefei, Anhui, Peoples R China

来源：

JOURNAL OF CANCER | 2021年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

GAS5; miRNA; glioma; chemosensitivity; CELL-PROLIFERATION; TUMOR-SUPPRESSOR; CANCER; INHIBITION; EXPRESSION; RECEPTOR; METASTASIS; RESISTANCE; ERLOTINIB; HOTAIR;

D O I：

10.7150/jca.49203

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioma is a malignant brain tumor with a generally poor prognosis. Dysregulation of a long non-coding RNA, GAS5, has been detected in numerous cancers, including glioma. Previous studies have suggested that GAS5 plays a significant functional role in glioma, affecting proliferation, metastasis, invasion, and apoptosis. In this review, we describe the roles and mechanisms of GAS5 in glioma. GAS5 may be a biomarker for diagnosis and prognosis, and even a potential target for glioma treatment, and therefore warrants further investigation.

引用

页码：224 / 231

页数：8

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